Signaling across cell membranes is fundamentally important for normal cellular function and for understanding many diseases. Signal transduction and molecular trafficking are intertwined in ways that make it impossible to truly understand mechanisms of either in isolation. We propose to create a Center of Biomedical Research Excellence (COBRE) at the University of Nevada, Reno (UNR) in the area of cell biology of signaling across membranes. This COBRE will make significant progress in the emerging fusion of the fields of membrane trafficking and signal transduction by examining how molecular signaling is achieved across membranes, both between cells and between subcellular compartments. Five junior faculty with outstanding research accomplishments will use diverse and uniquely advantageous model systems where critical aspects of signaling and transport functions can be examined by molecular, genetic and structural approaches. The proposed research topics will utilize interdisciplinary approaches in the field of signal transduction and molecular trafficking, including growth factor signaling, regulation of gene expression, nuclear and cytoplasmic transport, secretion, endocytosis, apoptosis, and axon guidance. The proposed COBRE is a comprehensive effort that will integrate high-quality biomedical research and expertise in different departments and colleges at UNR under one theme and program. This will bridge the traditional physical and administrative division between the Colleges of Science and Medicine on the upper and lower campus at UNR, and foster interactions that lead to synergism and enhanced biomedical research capacity. The COBRE will provide an efficient mentoring program for junior faculty that will expand already existing training programs at UNR, and support the research of selected young faculty by teaming with clinical mentors and consultants to establish disease focus. The COBRE will provide enhanced infrastructure and technical support for Nevada's new generation of biomedical researchers with truly outstanding credentials and promise for major achievements in biomedical research.

Public Health Relevance

Signaling across cell membranes is fundamentally important for normal cellular function and for understanding many diseases, ranging from cancer (abnormal proliferation) to neurodegenerative diseases (abnormal trophic signaling). The common and ultimate overall research goal of this proposal is to understand, and eventually manipulate, fundamental processes of signaling in cell biology that are relevant for human disorders, including cancer, immunological and neurological diseases and enteric malformations.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
3P20GM103554-05S1
Application #
9323151
Study Section
Special Emphasis Panel (ZRR1-RI-3 (01))
Program Officer
Liu, Yanping
Project Start
2011-09-15
Project End
2017-07-31
Budget Start
2015-08-01
Budget End
2017-07-31
Support Year
5
Fiscal Year
2016
Total Cost
$244,063
Indirect Cost
$28,135
Name
University of Nevada Reno
Department
Physiology
Type
Schools of Medicine
DUNS #
146515460
City
Reno
State
NV
Country
United States
Zip Code
89557
Dagda, Ruben K; Rice, Monica (2017) Protocols for assessing mitophagy in neuronal cell lines and primary neurons. Neuromethods 123:249-277
Bahney, Jami; von Bartheld, Christopher S (2017) The Cellular Composition and Glia-Neuron Ratio in the Spinal Cord of a Human and a Nonhuman Primate: Comparison With Other Species and Brain Regions. Anat Rec (Hoboken) :
Agarwal, Andrea B; Christensen, Austin J; Feng, Cheng-Yuan et al. (2017) Expression of schizophrenia biomarkers in extraocular muscles from patients with strabismus: an explanation for the link between exotropia and schizophrenia? PeerJ 5:e4214
Godoy, Luis D; Lucas, Julianna E; Bender, Abigail J et al. (2017) Targeting the epigenome: Screening bioactive compounds that regulate histone deacetylase activity. Mol Nutr Food Res 61:
Justice, Elizabeth D; Barnum, Sarah J; Kidd, Thomas (2017) The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene. PLoS Genet 13:e1006865
Feyertag, Felix; Berninsone, Patricia M; Alvarez-Ponce, David (2017) Secreted Proteins Defy the Expression Level-Evolutionary Rate Anticorrelation. Mol Biol Evol 34:692-706
Sarathy, Apurva; Wuebbles, Ryan D; Fontelonga, Tatiana M et al. (2017) SU9516 Increases ?7?1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy. Mol Ther 25:1395-1407
Kim, Minkyung; Fontelonga, Tatiana M; Lee, Clare H et al. (2017) Motor axons are guided to exit points in the spinal cord by Slit and Netrin signals. Dev Biol 432:178-191
Kim, Minkyung; Bjorke, Brielle; Mastick, Grant S (2017) Motor neuron migration and positioning mechanisms: New roles for guidance cues. Semin Cell Dev Biol :
Sacoman, Juliana L; Dagda, Raul Y; Burnham-Marusich, Amanda R et al. (2017) Mitochondrial O-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells. J Biol Chem 292:4499-4518

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