The primary goal of this application is to strengthen the bionnedical research infrastructure at Sanford Research/The University of South Dakota (USD) through establishment of the Center for Pediatric Research. This multidisciplinary Center would encompass a foundation of basic scientists, clinical mentors and core services to enhance the study of developmental abnormalities resulting in childhood disease. The origin of many pediatric health problems stem from alterations in one of five basic cellular processes: proliferation, morphogenesis, migration, differentiation and programmed cell death. Utilizing a multidisciplinary approach that integrates a better understanding of each of these developmental phases combined with direction from clinicians treating patients affected by these cellular abnormalities will cultivate a biomedical research center with broader knowledge depth and a unique translational understanding. A major function of the Center will be to support early stage investigators in their efforts to become independent scientists that flourish in their field. Center activities require administrative oversight to ensure successful completion of Center objectives. Through these activities, the Administrative Core will provide organization, oversight, and evaluation of Center efforts to foster a supportive and collaborative pediatric research environment.
Aim 1 will create a supportive environment for the training and mentorship of basic scientists.
Aim 2 will establish three new technical cores to support scientific goals of the Center.
Aim 3 will promote translational approaches to basic science research while educating clinicians about scientific advancements in their field.
Aim 4 proposes to raise the profile of the Center by expanding post-doctoral and student training, and community outreach programs.
Aim 5 will implement an evaluation program designed to track Center progress. Through these aims, the Center for Pediatric Research will develop a strong foundation in basic and translational research that fosters a collaborative and supportive environment to conduct state-of-the-art research of developmental pediatric disease.

Public Health Relevance

The Center for Pediatric Research will assemble and mentor early-stage investigators studying the underlying basis of childhood disease and direct. The Administrative Core will oversee administrative, scientific, and fiscal aspects of the Center and help scientists development innovative ideas towards preventing, diagnosing, and treating pediatric diseases and disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
1P20GM103620-01A1
Application #
8465598
Study Section
Special Emphasis Panel (ZGM1-TWD-B (CB))
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$385,854
Indirect Cost
$144,695
Name
Sanford Research/Usd
Department
Type
DUNS #
050113252
City
Sioux Falls
State
SD
Country
United States
Zip Code
57104
Guo, Qiusha; Wang, Yinqiu; Tripathi, Piyush et al. (2015) Adam10 mediates the choice between principal cells and intercalated cells in the kidney. J Am Soc Nephrol 26:149-59
Kim, Dae In; Birendra, K C; Zhu, Wenhong et al. (2014) Probing nuclear pore complex architecture with proximity-dependent biotinylation. Proc Natl Acad Sci U S A 111:E2453-61
Haugrud, Allison B; Zhuang, Yongxian; Coppock, Joseph D et al. (2014) Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells. Breast Cancer Res Treat 147:539-50
Finn, R; Evans, C C; Lee, L (2014) Strain-dependent brain defects in mouse models of primary ciliary dyskinesia with mutations in Pcdp1 and Spef2. Neuroscience 277:552-67
Floen, Miranda J; Forred, Benjamin J; Bloom, Elliot J et al. (2014) Thioredoxin-1 redox signaling regulates cell survival in response to hyperoxia. Free Radic Biol Med 75:167-77
Surendran, Kameswaran; Vitiello, Seasson P; Pearce, David A (2013) Lysosome dysfunction in the pathogenesis of kidney diseases. Pediatr Nephrol :