The major goal of this COBRE application is to foster the development of COBRE investigators in the Center of Pediatric Research and help them to succeed in their research programs. This will be carried out by a multidisciplinary group of researchers at Sanford Research/USD who are dedicated to basic and translational biomedical research. To promote the growth of the only multidisciplinary training program for pediatric basic and translational studies in South Dakota, the Sanford Research/USD will establish infrastructures to provide essential and centralized laboratory service to COBRE project leaders. The Molecular Genetics Core facility is a laboratory in the Children's Health Research Center offering efficient, high quality and affordable molecular genetics services for COBRE project leaders and other researchers in Sanford Research/USD. The state-of-the-art, high-throughput equipment in the laboratory will enable a wide range of molecular genetics assays, including extraction of nucleic acids from tissues and cells, quantitative and qualitative analysis of nucleic acid samples, gene expression analysis and training. The Molecular Genetics Core facility will provide personalized services for COBRE project leaders from experimental design to assay execution and data analysis. A plan is developed for a sustainable Molecular Genetics Core facility to serve the needs of COBRE project leaders and other researchers in Sanford Research/USD. By providing the funding, resources and core lab services, Sanford Research/USD will promote the advancement of this core group of scientists to build a stronger pediatric research program, and ultimately increase the number of NlH-funded biomedical researchers in South Dakota.
The Molecular Genetics Core will provide services and expertise for molecular genetic assays and techniques. These services are critical for advancing studies involving elucidation of gene function in health and disease.
|Forred, Benjamin J; Neuharth, Skyla; Kim, Dae In et al. (2016) Identification of Redox and Glucose-Dependent Txnip Protein Interactions. Oxid Med Cell Longev 2016:5829063|
|Rickel, Kirby; Fang, Fang; Tao, Jianning (2016) Molecular genetics of osteosarcoma. Bone :|
|Kim, Dae In; Jensen, Samuel C; Noble, Kyle A et al. (2016) An improved smaller biotin ligase for BioID proximity labeling. Mol Biol Cell 27:1188-96|
|White, Katherine A; Hutton, Scott R; Weimer, Jill M et al. (2016) Diet-induced obesity prolongs neuroinflammation and recruits CCR2(+) monocytes to the brain following herpes simplex virus (HSV)-1 latency in mice. Brain Behav Immun 57:68-78|
|Simpkins, Jessica A; Rickel, Kirby E; Madeo, Marianna et al. (2016) Disruption of a cystine transporter downregulates expression of genes involved in sulfur regulation and cellular respiration. Biol Open 5:689-97|
|Booze, Michelle L; Hansen, Jason M; Vitiello, Peter F (2016) A novel mouse model for the identification of thioredoxin-1 protein interactions. Free Radic Biol Med 99:533-543|
|Yao, Qingqing; Liu, Yangxi; Tao, Jianning et al. (2016) Hypoxia-mimicking nanofibrous scaffolds promote endogenous bone regeneration. ACS Appl Mater Interfaces :|
|Alam, Samer G; Zhang, Qiao; Prasad, Nripesh et al. (2016) The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity. Sci Rep 6:38063|
|Mdaki, Kennedy S; Larsen, Tricia D; Wachal, Angela L et al. (2016) Maternal high-fat diet impairs cardiac function in offspring of diabetic pregnancy through metabolic stress and mitochondrial dysfunction. Am J Physiol Heart Circ Physiol 310:H681-92|
|Baack, Michelle L; Puumala, Susan E; Messier, Stephen E et al. (2016) Daily Enteral DHA Supplementation Alleviates Deficiency in Premature Infants. Lipids 51:423-33|
Showing the most recent 10 out of 30 publications