The primary goal of this application is to strengthen the bionnedical research infrastructure at Sanford Research/The University of South Dakota (USD) through establishment of the Center for Pediatric Research. This multidisciplinary Center would encompass a foundation of basic scientists, clinical mentors and core services to enhance the study of developmental abnormalities resulting in childhood disease. The origin of many pediatric health problems stem from alterations in one of five basic cellular processes: proliferation, morphogenesis, migration, differentiation and programmed cell death. Utilizing a multidisciplinary approach that integrates a better understanding of each of these developmental phases combined with direction from clinicians treating patients affected by these cellular abnormalities will cultivate a biomedical research center with broader knowledge depth and a unique translational understanding. A major function of the Center will be to support early stage investigators in their efforts to become independent scientists that flourish in their field. Center activities require administrative oversight to ensure successful completion of Center objectives. Through these activities, the Administrative Core will provide organization, oversight, and evaluation of Center efforts to foster a supportive and collaborative pediatric research environment.
Aim 1 will create a supportive environment for the training and mentorship of basic scientists.
Aim 2 will establish three new technical cores to support scientific goals of the Center.
Aim 3 will promote translational approaches to basic science research while educating clinicians about scientific advancements in their field.
Aim 4 proposes to raise the profile of the Center by expanding post-doctoral and student training, and community outreach programs.
Aim 5 will implement an evaluation program designed to track Center progress. Through these aims, the Center for Pediatric Research will develop a strong foundation in basic and translational research that fosters a collaborative and supportive environment to conduct state-of-the-art research of developmental pediatric disease.
The Center for Pediatric Research will assemble and mentor early-stage investigators studying the underlying basis of childhood disease and direct. The Administrative Core will oversee administrative, scientific, and fiscal aspects of the Center and help scientists development innovative ideas towards preventing, diagnosing, and treating pediatric diseases and disorders.
|Forred, Benjamin J; Neuharth, Skyla; Kim, Dae In et al. (2016) Identification of Redox and Glucose-Dependent Txnip Protein Interactions. Oxid Med Cell Longev 2016:5829063|
|Rickel, Kirby; Fang, Fang; Tao, Jianning (2016) Molecular genetics of osteosarcoma. Bone :|
|Kim, Dae In; Jensen, Samuel C; Noble, Kyle A et al. (2016) An improved smaller biotin ligase for BioID proximity labeling. Mol Biol Cell 27:1188-96|
|White, Katherine A; Hutton, Scott R; Weimer, Jill M et al. (2016) Diet-induced obesity prolongs neuroinflammation and recruits CCR2(+) monocytes to the brain following herpes simplex virus (HSV)-1 latency in mice. Brain Behav Immun 57:68-78|
|Simpkins, Jessica A; Rickel, Kirby E; Madeo, Marianna et al. (2016) Disruption of a cystine transporter downregulates expression of genes involved in sulfur regulation and cellular respiration. Biol Open 5:689-97|
|Booze, Michelle L; Hansen, Jason M; Vitiello, Peter F (2016) A novel mouse model for the identification of thioredoxin-1 protein interactions. Free Radic Biol Med 99:533-543|
|Yao, Qingqing; Liu, Yangxi; Tao, Jianning et al. (2016) Hypoxia-mimicking nanofibrous scaffolds promote endogenous bone regeneration. ACS Appl Mater Interfaces :|
|Alam, Samer G; Zhang, Qiao; Prasad, Nripesh et al. (2016) The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity. Sci Rep 6:38063|
|Mdaki, Kennedy S; Larsen, Tricia D; Wachal, Angela L et al. (2016) Maternal high-fat diet impairs cardiac function in offspring of diabetic pregnancy through metabolic stress and mitochondrial dysfunction. Am J Physiol Heart Circ Physiol 310:H681-92|
|Baack, Michelle L; Puumala, Susan E; Messier, Stephen E et al. (2016) Daily Enteral DHA Supplementation Alleviates Deficiency in Premature Infants. Lipids 51:423-33|
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