The Administrative and Scientific Development Core (Core A) will provide administrative, fiscal, and scientific support for the proposed Center for Microbial Pathogenesis and Host Inflammatory Responses by operating and maintaining a COBRE Center (Aim 1), fostering scientific growth through mentoring and faculty development (Aim 2), and fostering growth and expansion of the COBRE Center and its programs (Aim 3). The Center's goal is to address infectious disease in a therapeutically relevant fashion by understanding both the microbial virulence factors that contribute to the disease process and how these factors impact the host immunological and inflammatory response to determine the ultimate clinical outcome. The Administrative and Scientific Development Core will rely on Internal and External Advisory Committees, experienced mentors, and a seasoned administrative team operating under the leadership of the Center Director to guide four Project Leaders who focus on the Center's theme to independent external funding. The Core's leadership team will also develop a "pipeline" of potential Project Leaders, junior investigators and experienced scientists who are interested in becoming active in research regarding microbial pathogens and host response and will continue to support Project Leaders who have "graduated" to external funding at the ROI level. This Core will also train new mentors, initiate a Distinguished Lecturer Series to attract new scientists to the field, provide pilot funding to encourage new research, and evaluate the Center and its projects. Successful operation of this Core will enable the Center to achieve the following milestones within 5 years of funding: 3 independently funded new PIs associated with the Center, 2-4 new mentors, 3-5 potential new Project Leaders, 8-15 publications in peer-reviewed journals, and 1 program project grant in the early stages of planning.

Public Health Relevance

of this Core relates to its role in supporting a Center that will address the persistent problem of infectious disease, specifically the role of pathogens and their impact on the body's immunological and inflammatory response. This Core will provide administrative, fiscal, and scientific support for scientists who will investigate complex interactions between microbial pathogens and their human hosts from the perspectives of both the pathogen itself and the host response. Their work has the potential to significantly enhance the ability to control the devastating consequences of many infectious diseases, including those caused by pathogens that are resistant to antibiotics.

Agency
National Institute of Health (NIH)
Type
Exploratory Grants (P20)
Project #
5P20GM103625-03
Application #
8652482
Study Section
Special Emphasis Panel (ZRR1)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Kothari, Anisha; Hittelman, Walter N; Chambers, Timothy C (2016) Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells. Cancer Res 76:3553-61
Sengupta, Deepanwita; Tackett, Alan J (2016) Proteomic Findings in Melanoma. J Proteomics Bioinform 9:
Byrd, Alicia K; Zybailov, Boris L; Maddukuri, Leena et al. (2016) Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress. J Biol Chem 291:18041-57
Fujiwara, T; Zhou, J; Ye, S et al. (2016) RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival. Cell Death Dis 7:e2300
Jolly, Lee Ann; Novitskiy, Sergey; Owens, Phillip et al. (2016) Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss. Cancer Res 76:1804-13
Liem, Jason; Liu, Jia (2016) Stress Beyond Translation: Poxviruses and More. Viruses 8:
Atanassov, Boyko S; Mohan, Ryan D; Lan, Xianjiang et al. (2016) ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth. Mol Cell 62:558-71
Atwood, Danielle N; Beenken, Karen E; Lantz, Tamara L et al. (2016) Regulatory Mutations Impacting Antibiotic Susceptibility in an Established Staphylococcus aureus Biofilm. Antimicrob Agents Chemother 60:1826-9
Sifford, Jeffrey M; Stahl, James A; Salinas, Eduardo et al. (2016) Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication. J Virol 90:2571-85
Byrum, Stephanie D; Burdine, Marie S; Orr, Lisa et al. (2016) A Quantitative Proteomic Analysis of Urine from Gamma-Irradiated Non-Human Primates. J Proteomics Bioinform 9:

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