The objective of this COBRE application is to develop the careers of promising junior investigators in biomedical aging research and to build programmatic strength in this area. Career development will utilize a strong core of research mentors who will provide career development advice as well as sound practical advice on scientific development and laboratory management. The five projects in this COBRE focus on several complementary themes that contribute to our understanding of aging, from basic genetic and epigenetic contributions through cardiovascular and neurocognitive mechanisms. Three of the projects feature human aging, one focuses on rodent models, and one utilizes cultured cells. All of the projects have a high translational relevance. An internal advisory committee consisting of seasoned scientist/administrators has been appointed. The COBRE leadership is composed of mentors and core senior investigators for this COBRE, and they are strongly committed to the program;these scientists have outstanding research and mentoring records. In addition, a prominent board of external advisors with outstanding research careers and track records of career development for junior scientists will participate in both the guidance and evaluation of the progress of the junior investigators and of the COBRE program itself. Career development will involve a series of program meetings, exposure to didactic grant-writing sessions, and seminars to develop a highly collaborative environment for both the junior faculty, as well as other members of the Tulane Center for Aging. The COBRE also provides a Biostatistics and Genomics Research Core facility for our scientists to make new experimental possibilities available to them and to enhance experimental design and data analysis. The Tulane Center for Aging provides an outstanding interdisciplinary environment for aging research involving eight of the schools at Tulane University. The Center enjoys strong institutional support for its development and growth. This COBRE will represent the centerpiece of the Tulane Center for Aging, and it will contribute strongly to our building of an exceptional biomedical aging research enterprise in Louisiana.

Public Health Relevance

This COBRE will have major impact on the success of a number of our young faculty in obtaining their first NIH ROI funding. This will greatly enhance the research funding base and mentoring pool in Louisiana and especially in the area of biomedical aging research. In addition, the scientific programs and cores described here provide outstanding and highly translational projects aimed at the development of preventive and compensatory measures to enhance the quality of life in an aging population.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Canto, Maria Teresa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Tulane University
Internal Medicine/Medicine
Schools of Medicine
New Orleans
United States
Zip Code
Guo, Weichao; Saito, Shigeki; Sanchez, Cecilia G et al. (2017) TGF-?1 stimulates HDAC4 nucleus-to-cytoplasm translocation and NADPH oxidase 4-derived reactive oxygen species in normal human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 312:L936-L944
Liao, Wenjuan; Liu, Hongbing; Zhang, Yiwei et al. (2017) Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid Metabolism. Sci Rep 7:9020
Jazwinski, S Michal; Kim, Sangkyu (2017) Metabolic and Genetic Markers of Biological Age. Front Genet 8:64
Palozola, Katherine C; Donahue, Greg; Liu, Hong et al. (2017) Mitotic transcription and waves of gene reactivation during mitotic exit. Science 358:119-122
Jazwinski, S Michal; Jiang, James C; Kim, Sangkyu (2017) Adaptation to metabolic dysfunction during aging: Making the best of a bad situation. Exp Gerontol :
Motherwell, Jessica M; Azimi, Mohammad S; Spicer, Kristine et al. (2017) Evaluation of Arteriolar Smooth Muscle Cell Function in an Ex Vivo Microvascular Network Model. Sci Rep 7:2195
Sweat, Richard S; Sloas, David C; Stewart, Scott A et al. (2017) Aging is associated with impaired angiogenesis, but normal microvascular network structure, in the rat mesentery. Am J Physiol Heart Circ Physiol 312:H275-H284
Kim, Sangkyu; Myers, Leann; Wyckoff, Jennifer et al. (2017) The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age. Geroscience 39:83-92
Azimi, Mohammad S; Motherwell, Jessica M; Murfee, Walter L (2017) An Ex Vivo Method for Time-Lapse Imaging of Cultured Rat Mesenteric Microvascular Networks. J Vis Exp :
Molinski, Steven V; Shahani, Vijay M; MacKinnon, Stephen S et al. (2017) Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474. Biochem Biophys Res Commun 483:502-508

Showing the most recent 10 out of 65 publications