The objective of this COBRE application is to develop the careers of promising junior investigators in biomedical aging research and to build programmatic strength in this area. Career development will utilize a strong core of research mentors who will provide career development advice as well as sound practical advice on scientific development and laboratory management. The five projects in this COBRE focus on several complementary themes that contribute to our understanding of aging, from basic genetic and epigenetic contributions through cardiovascular and neurocognitive mechanisms. Three of the projects feature human aging, one focuses on rodent models, and one utilizes cultured cells. All of the projects have a high translational relevance. An internal advisory committee consisting of seasoned scientist/administrators has been appointed. The COBRE leadership is composed of mentors and core senior investigators for this COBRE, and they are strongly committed to the program;these scientists have outstanding research and mentoring records. In addition, a prominent board of external advisors with outstanding research careers and track records of career development for junior scientists will participate in both the guidance and evaluation of the progress of the junior investigators and of the COBRE program itself. Career development will involve a series of program meetings, exposure to didactic grant-writing sessions, and seminars to develop a highly collaborative environment for both the junior faculty, as well as other members of the Tulane Center for Aging. The COBRE also provides a Biostatistics and Genomics Research Core facility for our scientists to make new experimental possibilities available to them and to enhance experimental design and data analysis. The Tulane Center for Aging provides an outstanding interdisciplinary environment for aging research involving eight of the schools at Tulane University. The Center enjoys strong institutional support for its development and growth. This COBRE will represent the centerpiece of the Tulane Center for Aging, and it will contribute strongly to our building of an exceptional biomedical aging research enterprise in Louisiana.

Public Health Relevance

This COBRE will have major impact on the success of a number of our young faculty in obtaining their first NIH ROI funding. This will greatly enhance the research funding base and mentoring pool in Louisiana and especially in the area of biomedical aging research. In addition, the scientific programs and cores described here provide outstanding and highly translational projects aimed at the development of preventive and compensatory measures to enhance the quality of life in an aging population.

Agency
National Institute of Health (NIH)
Type
Exploratory Grants (P20)
Project #
5P20GM103629-03
Application #
8663291
Study Section
Special Emphasis Panel (ZRR1)
Program Officer
Arora, Krishan
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Tulane University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Zhang, Yanqing; Fava, Genevieve E; Wang, Hongjun et al. (2016) PAX4 Gene Transfer Induces α-to-β Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes Treatment. Mol Ther 24:251-60
Burks, Hope E; Phamduy, Theresa B; Azimi, Mohammad S et al. (2016) Laser Direct-Write Onto Live Tissues: A Novel Model for Studying Cancer Cell Migration. J Cell Physiol 231:2333-8
Boraas, Liana C; Ahsan, Tabassum (2016) Lack of vimentin impairs endothelial differentiation of embryonic stem cells. Sci Rep 6:30814
Zhou, Xiang; Hao, Qian; Liao, Peng et al. (2016) Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator. Elife 5:
Mock, Jeffrey R; Foundas, Anne L; Golob, Edward J (2016) Cortical activity during cued picture naming predicts individual differences in stuttering frequency. Clin Neurophysiol 127:3093-101
Yariswamy, Manjunath; Yoshida, Tadashi; Valente, Anthony J et al. (2016) Cardiac-restricted Overexpression of TRAF3 Interacting Protein 2 (TRAF3IP2) Results in Spontaneous Development of Myocardial Hypertrophy, Fibrosis, and Dysfunction. J Biol Chem 291:19425-36
Sloas, David C; Stewart, Scott A; Sweat, Richard S et al. (2016) Estimation of the Pressure Drop Required for Lymph Flow through Initial Lymphatic Networks. Lymphat Res Biol 14:62-9
Quijano, Lina M; Lynch, Kristen M; Allan, Christopher H et al. (2016) Looking Ahead to Engineering Epimorphic Regeneration of a Human Digit or Limb. Tissue Eng Part B Rev 22:251-62
Jiang, James C; Stumpferl, Stefan W; Tiwari, Anurag et al. (2016) Identification of the Target of the Retrograde Response that Mediates Replicative Lifespan Extension in Saccharomyces cerevisiae. Genetics 204:659-673
Wolfe, Russell P; Guidry, Julia B; Messina, Stephanie L et al. (2016) Applying Shear Stress to Pluripotent Stem Cells. Methods Mol Biol 1341:377-89

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