The overall goal of this core is to make equipment and expertise available to our Jls and other Tulane Center for Aging members that will allow them to be more productive investigators. This will provide capabilities to our investigators that either allows them to compete effectively with other investigators, or ideally allows them to carry out experiments more efficiently, or that are even not possible, at other institutions. The core facilities at the Tulane Center for Aging are an evolving entity. We do not intend to duplicate instrumentation readily accessible at other locations at Tulane or to provide resources that are more easily available to our investigators locally in their departments. The genomics core is an existing unit forged from equipment placed in the core by Dr. Jazwinski and purchased directly by the university. The lllumina Bead Station is the unique instrument in the Core that provides important capabilities for genetic and gene expression analyses. Our Jl's have broad based needs for DNA sequencing, genotyping, and gene expression analysis services that can be met by this core. They also need the bioinformatics and biostatistics support to analyze their data. We support both of these needs in our research core.
Our specific aims are: 1. To provide access, training, maintenance, and technical support for DNA sequencing, gene expression analysis, and high-throughput genotyping and gene expression services in our core, based on the high quality instrumentation available to our faculty. 2. To provide bioinformatics and biostatistics support to our investigators for analysis of the data they acquire in our core facility.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103629-03
Application #
8663293
Study Section
Special Emphasis Panel (ZRR1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Jazwinski, S Michal; Jiang, James C; Kim, Sangkyu (2018) Adaptation to metabolic dysfunction during aging: Making the best of a bad situation. Exp Gerontol 107:87-90
Zhang, Qian; Chen, Yujue; Yang, Lu et al. (2018) Multitasking Ska in Chromosome Segregation: Its Distinct Pools Might Specify Various Functions. Bioessays 40:
Kim, Sangkyu; Jazwinski, S Michal (2018) The Gut Microbiota and Healthy Aging: A Mini-Review. Gerontology 64:513-520
Boraas, Liana C; Pineda, Emma T; Ahsan, Tabassum (2018) Actin and myosin II modulate differentiation of pluripotent stem cells. PLoS One 13:e0195588
Sure, Venkata N; Sakamuri, Siva S V P; Sperling, Jared A et al. (2018) A novel high-throughput assay for respiration in isolated brain microvessels reveals impaired mitochondrial function in the aged mice. Geroscience 40:365-375
Akintunde, Akinjide R; Miller, Kristin S (2018) Evaluation of microstructurally motivated constitutive models to describe age-dependent tendon healing. Biomech Model Mechanobiol 17:793-814
Kim, Sangkyu; Wyckoff, Jennifer; Morris, Anne-T et al. (2018) DNA methylation associated with healthy aging of elderly twins. Geroscience 40:469-484
Maffei, Vincent J; Kim, Sangkyu; Blanchard 4th, Eugene et al. (2017) Biological Aging and the Human Gut Microbiota. J Gerontol A Biol Sci Med Sci 72:1474-1482
Sweat, Richard S; Sloas, David C; Stewart, Scott A et al. (2017) Aging is associated with impaired angiogenesis, but normal microvascular network structure, in the rat mesentery. Am J Physiol Heart Circ Physiol 312:H275-H284
Azimi, Mohammad S; Motherwell, Jessica M; Murfee, Walter L (2017) An Ex Vivo Method for Time-Lapse Imaging of Cultured Rat Mesenteric Microvascular Networks. J Vis Exp :

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