The Administrative Core is responsible for a number of important activities related to the COBRE program, including organization ofthe annual symposium, the seed grant program, and communication with the oversight committees (EAC and lAC). Dr. West will direct the Administrative Core and will be responsible for all administrative functions ofthe COBRE program. She will be assisted by the Associate Program Director, Dr. Gillian Air, and a full-time staff assistant who will help manage financial and programmatic aspects ofthe Center. Funds to subsidize the user fees of the research core facilities by Junior Investigators will come from the Administrative Core.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103640-03
Application #
8666000
Study Section
Special Emphasis Panel (ZRR1-RI-B)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
$427,152
Indirect Cost
$142,384
Name
University of Oklahoma Norman
Department
Type
DUNS #
848348348
City
Norman
State
OK
Country
United States
Zip Code
73019
Hanigan, Marie H; Gillies, Elizabeth M; Wickham, Stephanie et al. (2015) Immunolabeling of gamma-glutamyl transferase 5 in normal human tissues reveals that expression and localization differ from gamma-glutamyl transferase 1. Histochem Cell Biol 143:505-15
Hanigan, Marie H (2014) Gamma-glutamyl transpeptidase: redox regulation and drug resistance. Adv Cancer Res 122:103-41
West, Matthew B; Chen, Yunyu; Wickham, Stephanie et al. (2014) Novel insights into eukaryotic ýý-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme. J Biol Chem 289:11569
Ding, Jingzhen; Mooers, Blaine H M; Zhang, Zhi et al. (2014) After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. J Biol Chem 289:11873-96
Sheikh, M Osman; Schafer, Christopher M; Powell, John T et al. (2014) Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein. Biochemistry 53:1657-69
West, Matthew B; Chen, Yunyu; Wickham, Stephanie et al. (2013) Novel insights into eukaryotic ýý-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme. J Biol Chem 288:31902-13
Wickham, Stephanie; Regan, Nicholas; West, Matthew B et al. (2013) Inhibition of human ýý-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors. Biochem J 450:547-57
Isom, Catherine E; Turner, Jessica L; Lessner, Daniel J et al. (2013) Redox-sensitive DNA binding by homodimeric Methanosarcina acetivorans MsvR is modulated by cysteine residues. BMC Microbiol 13:163
Thomas, Leonard M; Harper, Angelica R; Miner, Whitney A et al. (2013) Structure of Escherichia coli AdhP (ethanol-inducible dehydrogenase) with bound NAD. Acta Crystallogr Sect F Struct Biol Cryst Commun 69:730-2
Hill, Heather E; Pioszak, Augen A (2013) Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling. Protein Expr Purif 88:107-13