This COBRE application proposes to establish a Center for Dietary Supplements and Inflammation (CDSI) at the University of South Carolina (USC) that will pursue multidisciplinary research on how botanicals can modulate inflammation and be used to prevent and/or treat inflammatory diseases. Recently, USC has made significant strides to promote research in Complementary and Alternative Medicine (CAM) which has resulted in the award of a Program Project/Center grant to study CAM modalities to treat autoimmune diseases. Thus, the CDSI will complement the CAM program and create a unique niche at USC in inflammation research. The main goal of CDSI is to establish multi-disciplinary research that will identify the molecular mechanisms through which botanicals modulate inflammation so that they or their analogs can be used to prevent and/or treat inflammatory diseases. Americans spend~$33.9 billion/year on CAM, of which ~$20 billion is on dietary supplements. It is becoming increasingly clear that inflammation plays a critical role in the pathogenesis of not only autoimmune diseases but also a wide range of clinical disorders including cardiovascular diseases, neurodegenerative disorders, and cancer: areas under investigation in this study. Thus, understanding the mode of action of dietary supplements or their constituents on inflammation, could lead to novel treatment modalities with far ranging clinical implications. The CDSI goal will be accomplished through promotion of multi-disciplinary research pursued by 4 junior tenure-track faculty in the area of inflammatory diseases, through highly structured mentoring by eight senior faculty members, and providing them with state-of-the-art core facilities. The program will be evaluated by an External Advisory Committee consisting of nationally recognized scientists. Additionally, through institutional support, 10 new tenure-track junior faculty will be recruited and trained at USC to bolster and advance inflammation research. The long term objective of the CDSI would be to build a self-sustaining, nationally recognized multi-disciplinary Center for dietary supplements and inflammation research, by promoting innovation, faculty entrepreneurship, collaborative research projects (PPGs and Institutional Training grants), and clinical/translational research.

Public Health Relevance

Inflammation is considered to be the underlying cause of a larger number of diseases that afflict heart and brain, as well as cancer. We plan to establish a Center that will study how compounds found in dietary supplements (botanicals) can suppress inflammation so that they can be used to treat a wide range of diseases. This will be accomplished through mentoring highly accomplished junior investigators.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Special Emphasis Panel (ZRR1-RI-4 (01))
Program Officer
Caldwell, Sheila
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University of South Carolina at Columbia
Schools of Medicine
United States
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Bam, Marpe; Yang, Xiaoming; Sen, Souvik et al. (2017) Characterization of Dysregulated miRNA in Peripheral Blood Mononuclear Cells from Ischemic Stroke Patients. Mol Neurobiol :
Pate, Kayla M; Rogers, McCall; Reed, John Will et al. (2017) Anthoxanthin Polyphenols Attenuate A? Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease. CNS Neurosci Ther 23:135-144
Finnell, Julie E; Lombard, Calliandra M; Padi, Akhila R et al. (2017) Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences. PLoS One 12:e0172868
Finnell, Julie E; Lombard, Calliandra M; Melson, Michael N et al. (2017) The protective effects of resveratrol on social stress-induced cytokine release and depressive-like behavior. Brain Behav Immun 59:147-157
Shamran, Haidar; Singh, Narendra P; Zumbrun, Elizabeth E et al. (2017) Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation. Brain Behav Immun 59:10-20
Wood, Susan K; Valentino, Rita J (2017) The brain norepinephrine system, stress and cardiovascular vulnerability. Neurosci Biobehav Rev 74:393-400
Bam, M; Yang, X; Zumbrun, E E et al. (2017) Decreased AGO2 and DCR1 in PBMCs from War Veterans with PTSD leads to diminished miRNA resulting in elevated inflammation. Transl Psychiatry 7:e1222
Yanez, Maria; Blanchette, James; Jabbarzadeh, Ehsan (2017) Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds. Curr Pharm Des :
Chitrala, Kumaraswamy Naidu; Guan, Hongbing; Singh, Narendra P et al. (2017) CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice. Eur J Immunol 47:1188-1199
Wood, Christopher S; Valentino, Rita J; Wood, Susan K (2017) Individual differences in the locus coeruleus-norepinephrine system: Relevance to stress-induced cardiovascular vulnerability. Physiol Behav 172:40-48

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