Administrative Core Abstract The Administrative Core will provide oversight on all aspects of the COBRE. The main focus of this Core is to enhance the research quality and productivity of the target faculty in the area of Dietary Supplements and Inflammation so that they will be successful in competing for independent, major extramural funding such as the NIH R01 awards.
The specific aims are as follows: 1) To facilitate mentoring of target faculty, enhance use of research resources and monitor the transition of target faculty into independent, well-funded investigators. The Core will be responsible for organizing and integrating the scientific activities of the junior investigators and the mentors of the COBRE. It will organize the lAC and EAC meetings that will provide input to the Center Director in assessment of research progress of the target faculty and allocation of resources. The Core will foster synergistic research between the investigators within the Center and their laboratory personnel by providing an interactive environment that will be nurtured by conduct of formal discussions such as weekly seminars, journal clubs, annual retreat, research day presentations, as well as other informal interactions. It will also coordinate the use of state-of-art core facilities for research. 2) To recruit 10 new tenure-track junior faculty and provide them seed funds to initiate research on dietary supplements and inflammation. The Core will recruit an additional 10 tenure-track Assistant Professors at 5 different colleges to develop multi-disciplinary research. This will be accomplished through significant support from USC. Special consideration will be given to attracting women and underrepresented minorities. The Core will also assist in the recruitment of pre- and postdoctoral researchers, and other technical staff for target faculty. It will provide seed funds for pilot projects from junior investigators to pursue studies on dietary supplements against inflammatory diseases. 3) To oversee the financial and personnel management of all the projects and cores as well as develop long term goals. It will provide oversight in the day to day management of the Center. The Core will be responsible for communication with the university administration and other regulatory agencies. The Core will promote long term objectives of the COBRE that include: 1) advancement of innovation and entrepreneurial activity by the target faculty to enhance drug discovery, 2) helping faculty develop Startup companies, 3) Training target faculty to submit NIH SBIR/STTR grants, 4) develop NIH Program Project grants (PPGs) and 5) prepare for submission of NIH training grant for graduate students and post-doctoral fellows. 6) Facilitate clinical research and trials. Together, these activities should lead to the development of a critical mass of highly competitive scientists supported through NIH R01/Program Projects/Career Development Awards/Training Grants serving the local, regional and national unmet needs in the area of Dietary Supplements and Inflammation.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-4)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of South Carolina at Columbia
United States
Zip Code
Bam, Marpe; Yang, Xiaoming; Sen, Souvik et al. (2017) Characterization of Dysregulated miRNA in Peripheral Blood Mononuclear Cells from Ischemic Stroke Patients. Mol Neurobiol :
Pate, Kayla M; Rogers, McCall; Reed, John Will et al. (2017) Anthoxanthin Polyphenols Attenuate A? Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease. CNS Neurosci Ther 23:135-144
Finnell, Julie E; Lombard, Calliandra M; Padi, Akhila R et al. (2017) Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences. PLoS One 12:e0172868
Finnell, Julie E; Lombard, Calliandra M; Melson, Michael N et al. (2017) The protective effects of resveratrol on social stress-induced cytokine release and depressive-like behavior. Brain Behav Immun 59:147-157
Shamran, Haidar; Singh, Narendra P; Zumbrun, Elizabeth E et al. (2017) Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation. Brain Behav Immun 59:10-20
Wood, Susan K; Valentino, Rita J (2017) The brain norepinephrine system, stress and cardiovascular vulnerability. Neurosci Biobehav Rev 74:393-400
Bam, M; Yang, X; Zumbrun, E E et al. (2017) Decreased AGO2 and DCR1 in PBMCs from War Veterans with PTSD leads to diminished miRNA resulting in elevated inflammation. Transl Psychiatry 7:e1222
Yanez, Maria; Blanchette, James; Jabbarzadeh, Ehsan (2017) Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds. Curr Pharm Des :
Chitrala, Kumaraswamy Naidu; Guan, Hongbing; Singh, Narendra P et al. (2017) CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice. Eur J Immunol 47:1188-1199
Wood, Christopher S; Valentino, Rita J; Wood, Susan K (2017) Individual differences in the locus coeruleus-norepinephrine system: Relevance to stress-induced cardiovascular vulnerability. Physiol Behav 172:40-48

Showing the most recent 10 out of 122 publications