The University of Puerto Rico (UPR) Medical Sciences Campus proposes to establish a COBRE Center that will significantly strengthen the research infrastructure of the institution and that will impact biomedical investigation throughout the island.
The specific aims of this COBRE Center for Neuroplasticity at the University of Puerto Rico are to: 1) Foster development of junior investigators into competitive researchers working on projects with direct biomedical significance. An intensive mentoring program will be implemented with the goal of creating a """"""""culture of research"""""""" comparable to that of major research-intensive universities. 2) Provide a Neuroimaging and Electrophysiology Facility (NIEF) that will offer state-of-the-art instrumentation, training, and expertise to the neuroscienc community of Puerto Rico. The NIEF will be located in the Institute of Neurobiology, but will incorporate ultra-high-end instrumentation in the new Biomolecular Sciences Building (BSB) after the COBRE has become well-established at the Institute;3) Partner with IDeA Networks of Biomedical Research Excellence (INBRE) entities in Puerto Rico;4) Support programmatic activities that increase interdisciplinary collaborations at the basic research level. The major strengths of the proposed COBRE include: 1) the PI, who is both an accomplished researcher with extensive funding and advisory activities within the NIH, and an experienced administrator with a history of successful initiation of research and training programs;2) the team of young, aggressive and highly committed scientists;3) enhanced mentorship possibilities provided by the current level of intellectual and scientific accomplishment present at the Institute of Neurobiology;3) rational planning for the future by deployment of the new BSB as a centralized hub for integrated and collaborative research in the future of the COBRE Center for Neuroplasticity;4) the full commitment of the UPR Administration toward assuring the stated goals of the project. This UPR COBRE Center should define pathways and benchmarks for basic and translational research across the UPR system for the next decades.
This project will establish a multidisciplinary Center of Biomedical Research Excellence (COBRE Center for Neuroplasticity, addressing important neurological and behavioral disorders such as spinal cord injury, sleep dysfunction, and the genetic basis of neuroadaptation to stress. This platform will serve as a model for transforming the research enterprise in Puerto Rico into a more resource-effective and collaborative environment aligned with the NIH Roadmap.
|Delgado-Peraza, Francheska; Ahn, Kwang H; Nogueras-Ortiz, Carlos et al. (2016) Mechanisms of Biased Î²-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor. Mol Pharmacol 89:618-29|
|Padilla-Morales, Luis F; ColÃ³n-SÃ¡ez, JosÃ© O; GonzÃ¡lez-Nieves, Joel E et al. (2016) Functionality and stability data of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology. Data Brief 6:433-7|
|Duprey-DÃaz, Mildred V; Blagburn, Jonathan M; Blanco, Rosa E (2016) Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury. PLoS One 11:e0162626|
|Melendez, Roberto I; Roman, Cristina; Capo-Velez, Coral M et al. (2016) Decreased glial and synaptic glutamate uptake in the striatum of HIV-1 gp120 transgenic mice. J Neurovirol 22:358-65|
|ColÃ³n, Jennifer M; Torrado, Aranza I; Cajigas, Ãmbar et al. (2016) Tamoxifen Administration Immediately or 24 Hours after Spinal Cord Injury Improves Locomotor Recovery and Reduces Secondary Damage in Female Rats. J Neurotrauma 33:1696-708|
|Ramos, FÃ©lix M; Delgado-VÃ©lez, Manuel; Ortiz, Ãngel L et al. (2016) Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder. J Neurovirol 22:327-35|
|Nogueras-Ortiz, Carlos; Yudowski, Guillermo A (2016) The Multiple Waves of Cannabinoid 1 Receptor Signaling. Mol Pharmacol 90:620-626|
|Morales-Cruz, Moraima; Cruz-MontaÃ±ez, Alejandra; Figueroa, Cindy M et al. (2016) Combining Stimulus-Triggered Release and Active Targeting Strategies Improves Cytotoxicity of Cytochrome c Nanoparticles in Tumor Cells. Mol Pharm 13:2844-54|
|BÃ¡ez-PagÃ¡n, Carlos A; Del Hoyo-Rivera, Natalie; Quesada, Orestes et al. (2016) Heterogeneous Inhibition in Macroscopic Current Responses of Four Nicotinic Acetylcholine Receptor Subtypes by Cholesterol Enrichment. J Membr Biol 249:539-49|
|Martinez, Namyr A; Ayala, Alondra M; Martinez, Magdiel et al. (2016) Caveolin-1 Regulates the P2Y2 Receptor Signaling in Human 1321N1 Astrocytoma Cells. J Biol Chem 291:12208-22|
Showing the most recent 10 out of 58 publications