The University of Puerto Rico (UPR) Medical Sciences Campus proposes to establish a COBRE Center that will significantly strengthen the research infrastructure of the institution and that will impact biomedical investigation throughout the island.
The specific aims of this COBRE Center for Neuroplasticity at the University of Puerto Rico are to: 1) Foster development of junior investigators into competitive researchers working on projects with direct biomedical significance. An intensive mentoring program will be implemented with the goal of creating a """"""""culture of research"""""""" comparable to that of major research-intensive universities. 2) Provide a Neuroimaging and Electrophysiology Facility (NIEF) that will offer state-of-the-art instrumentation, training, and expertise to the neuroscienc community of Puerto Rico. The NIEF will be located in the Institute of Neurobiology, but will incorporate ultra-high-end instrumentation in the new Biomolecular Sciences Building (BSB) after the COBRE has become well-established at the Institute;3) Partner with IDeA Networks of Biomedical Research Excellence (INBRE) entities in Puerto Rico;4) Support programmatic activities that increase interdisciplinary collaborations at the basic research level. The major strengths of the proposed COBRE include: 1) the PI, who is both an accomplished researcher with extensive funding and advisory activities within the NIH, and an experienced administrator with a history of successful initiation of research and training programs;2) the team of young, aggressive and highly committed scientists;3) enhanced mentorship possibilities provided by the current level of intellectual and scientific accomplishment present at the Institute of Neurobiology;3) rational planning for the future by deployment of the new BSB as a centralized hub for integrated and collaborative research in the future of the COBRE Center for Neuroplasticity;4) the full commitment of the UPR Administration toward assuring the stated goals of the project. This UPR COBRE Center should define pathways and benchmarks for basic and translational research across the UPR system for the next decades.

Public Health Relevance

This project will establish a multidisciplinary Center of Biomedical Research Excellence (COBRE Center for Neuroplasticity, addressing important neurological and behavioral disorders such as spinal cord injury, sleep dysfunction, and the genetic basis of neuroadaptation to stress. This platform will serve as a model for transforming the research enterprise in Puerto Rico into a more resource-effective and collaborative environment aligned with the NIH Roadmap.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103642-02
Application #
8687677
Study Section
Special Emphasis Panel (ZGM1-TWD-B (CB))
Program Officer
Liu, Yanping
Project Start
2013-07-01
Project End
2018-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
$2,135,856
Indirect Cost
$679,531
Name
University of Puerto Rico Med Sciences
Department
Type
Schools of Medicine
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936
Alicea, Daniel; Perez, Marizabeth; Maldonado, Carolina et al. (2017) Cortactin Is a Regulator of Activity-Dependent Synaptic Plasticity Controlled by Wingless. J Neurosci 37:2203-2215
Figueroa, C M; Suárez, B N; Molina, A M et al. (2017) Smart Release Nano-formulation of Cytochrome C and Hyaluronic Acid Induces Apoptosis in Cancer Cells. J Nanomed Nanotechnol 8:
Hampel, Stefanie; McKellar, Claire E; Simpson, Julie H et al. (2017) Simultaneous activation of parallel sensory pathways promotes a grooming sequence in Drosophila. Elife 6:
Loza-Rosas, Sergio A; Vázquez-Salgado, Alexandra M; Rivero, Kennett I et al. (2017) Expanding the Therapeutic Potential of the Iron Chelator Deferasirox in the Development of Aqueous Stable Ti(IV) Anticancer Complexes. Inorg Chem 56:7788-7802
Nogueras-Ortiz, Carlos; Roman-Vendrell, Cristina; Mateo-Semidey, Gabriel E et al. (2017) Retromer stops beta-arrestin 1-mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28:3554-3561
Delgado-Peraza, Francheska; Ahn, Kwang H; Nogueras-Ortiz, Carlos et al. (2016) Mechanisms of Biased ?-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor. Mol Pharmacol 89:618-29
Padilla-Morales, Luis F; Colón-Sáez, José O; González-Nieves, Joel E et al. (2016) Functionality and stability data of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology. Data Brief 6:433-7
Velázquez-Marrero, Cristina; Burgos, Alexandra; García, José O et al. (2016) Alcohol Regulates BK Surface Expression via Wnt/?-Catenin Signaling. J Neurosci 36:10625-10639
Pézier, Adeline P; Jezzini, Sami H; Bacon, Jonathan P et al. (2016) Shaking B Mediates Synaptic Coupling between Auditory Sensory Neurons and the Giant Fiber of Drosophila melanogaster. PLoS One 11:e0152211
Quesada, Orestes; González-Freire, Carol; Ferrer, María Carla et al. (2016) Uncovering the lipidic basis for the preparation of functional nicotinic acetylcholine receptor detergent complexes for structural studies. Sci Rep 6:32766

Showing the most recent 10 out of 71 publications