The Administrative Core will support the three-fold objectives of the C OBRE Center: 1) Develop and maintain a nationally competitive biomedical research program focused on the theme of Neuroplasticity, 2) Facilitate the developmental trajectory of junior investigators toward their transition to independent research careers, and 3) Support the COBRE Neuroimaging and Electrophysiology Facility (NIEF). The three Specific Aims of the Administrative Core are to organize and sustain: 1) a structured approach to faculty development that will implement a systematic mentoring strategy for COBRE Subproject Pis and newly recruited neuroscience faculty, 2) faculty career development activities that will provide programmatic instruction in Laboratory Management, Grant Writing, Manuscript Preparation and additional topics designed to accelerate the scientific development of junior faculty, and 3) a research infrastructure enhancement program that fosters collaboration and enriches the entire neuroscience community. Infrastructure enhancement activities will include a COBRE Seminar Series, a Neuroscientist-in-Residence program, the Annual Puerto Rico Neuroscience Conference, and an annual COBRE Center for Neuroplasticity Retreat and Assessment Activity. Teams composed of local and external mentors will provide guidance and direction aimed to promote advancement of COBRE investigators toward independence and their subsequent retention at the University of Puerto Rico. An External Advisory Committee (EAC), composed of Ieading neuroscientists who are committed to advancing neuroscience on the island, has been enlisted to provide guidance and to advocate on local and international levels. The Administrative Core will be centered at the Institute of Neurobiology, a freestanding unit of the University of Puerto Rico Medical Sciences Campus. Executive and fiscal program management will be implemented by a team of personnel with a proven track record in the operation and management of large multi-faceted research and training programs. This Administrative Core will be responsible for all purchasing, hiring, and reporting aspects of the COBRE Center. Finally, the COBRE Administrative Core will serve as liaison between program elements and an evaluation module that will provide: 1) ongoing formative feedback intended to assess COBRE Center strengths and areas requiring adjustment, and 2) summative assessments of program accomplishments and limitations.

Public Health Relevance

This Administrative Core will play an integral part in coordinating all managerial facets of the COBRE Center for Neuroplasticity. It will thereby facilitate the goal of the Center to create an innovative state-of the- art research center at the University of Puerto Rico.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103642-02
Application #
8687678
Study Section
Special Emphasis Panel (ZGM1-TWD-B)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
$546,107
Indirect Cost
$180,369
Name
University of Puerto Rico Med Sciences
Department
Type
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936
Ferré, Sergi; Díaz-Ríos, Manuel; Salamone, John D et al. (2018) New Developments on the Adenosine Mechanisms of the Central Effects of Caffeine and Their Implications for Neuropsychiatric Disorders. J Caffeine Adenosine Res 8:121-131
Delgado-Vélez, Manuel; Lasalde-Dominicci, José A (2018) The Cholinergic Anti-Inflammatory Response and the Role of Macrophages in HIV-Induced Inflammation. Int J Mol Sci 19:
Rivera-Oliver, Marla; Moreno, Estefanía; Álvarez-Bagnarol, Yocasta et al. (2018) Adenosine A1-Dopamine D1 Receptor Heteromers Control the Excitability of the Spinal Motoneuron. Mol Neurobiol :
Capó-Vélez, Coral M; Delgado-Vélez, Manuel; Báez-Pagán, Carlos A et al. (2018) Nicotinic Acetylcholine Receptors in HIV: Possible Roles During HAND and Inflammation. Cell Mol Neurobiol :
Saxena, Manoj; Delgado, Yamixa; Sharma, Rohit Kumar et al. (2018) Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate. PLoS One 13:e0195542
Thapa, Bibek; Diaz-Diestra, Daysi; Santiago-Medina, Carlene et al. (2018) T1- and T2-weighted Magnetic Resonance Dual Contrast by Single Core Truncated Cubic Iron Oxide Nanoparticles with Abrupt Cellular Internalization and Immune Evasion. ACS Appl Bio Mater 1:79-89
Vaasjo, Lee O; Quintana, Alexandra M; Habib, Mohamed R et al. (2018) GABA-like immunoreactivity in Biomphalaria: Colocalization with tyrosine hydroxylase-like immunoreactivity in the feeding motor systems of panpulmonate snails. J Comp Neurol 526:1790-1805
Capó-Vélez, Coral M; Morales-Vargas, Bryan; García-González, Aurian et al. (2018) The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders. Sci Rep 8:1829
Colón, Jennifer M; González, Pablo A; Cajigas, Ámbar et al. (2018) Continuous tamoxifen delivery improves locomotor recovery 6h after spinal cord injury by neuronal and glial mechanisms in male rats. Exp Neurol 299:109-121
Alicea, Daniel; Perez, Marizabeth; Maldonado, Carolina et al. (2017) Cortactin Is a Regulator of Activity-Dependent Synaptic Plasticity Controlled by Wingless. J Neurosci 37:2203-2215

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