The University of Puerto Rico (UPR) Medical Sciences Campus proposes to sustain and expand its COBRE Center for Neuroplasticity. The second phase of Center operation will significantly strengthen the research infrastructure of the institution and will impact biomedical investigation throughout the island.
The specific aims of the COBRE Center for Neuroplasticity at the University of Puerto Rico are: 1) Foster development of junior investigators into competitive researchers working on projects with direct biomedical significance. Our Phase I intensive mentoring program will be further strengthened with the goal of continued development of a competitive research culture; 2) Maintain and augment the NeuroImaging and Electrophysiology Facility (NIEF) established under COBRE Phase I. This multi-site core facility provides state-of-the-art instrumentation, training, and expertise to the research community of Puerto Rico. The NIEF is centered at the Molecular Sciences Research Center (MSRC) a major UPR infrastructure investment that is strategically positioned to enhance collaborative efforts between the major UPR campuses. The MSRC also serves numerous institutions associated with partnering IDeA Networks of Biomedical Research Excellence (INBRE); 3) Support programmatic activities (COBRE Seminar Series, Annual Puerto Rico Neuroscience Conference, COBRE Symposia, Workshops) that increase interdisciplinary collaborations at the basic research level. It is anticipated that these activities will significantly strengthen the entire biomedical research infrastructure and will stimulate collaborative investigation leading to translational research projects. The major strengths of this proposed COBRE Phase II initiative include: 1) the Program Director, who is both an accomplished researcher with extensive funding and advisory activities within the NIH and an experienced administrator with a history of successful initiation of research and training programs; 2) an experienced and effective Administrative Core; 3) a team of young, aggressive and highly committed early career scientists; 4) deployment of the new MSRC as a centralized hub for integrated and collaborative research; 5) the full commitment of the UPR Administration toward assuring the stated goals of the project. The COBRE Center for Neuroplasticity at the University of Puerto Rico is defining pathways and benchmarks for basic and translational research across the UPR system. Its second phase will ensure the sustained growth and evolution of a program that will advance the trajectory of competitive biomedical research in Puerto Rico over the next decades.

Public Health Relevance

. This Center for Biomedical Research Excellence (COBRE) Phase II initiative will support the COBRE Center for Neuroplasticity at the University of Puerto Rico. This interdisciplinary multi-campus center will implement improvements to the research infrastructure of Puerto Rico and will support a critical mass of investigators with shared scientific interests in the neurosciences. The Center for Neuroplasticity will also identify and promote academic-industry partnerships and opportunities for knowledge-based economic development.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103642-06
Application #
9360842
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Krasnova, Irina N
Project Start
2013-07-01
Project End
2023-06-30
Budget Start
2018-07-16
Budget End
2019-06-30
Support Year
6
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Puerto Rico Med Sciences
Department
Type
Overall Medical
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
Ferré, Sergi; Díaz-Ríos, Manuel; Salamone, John D et al. (2018) New Developments on the Adenosine Mechanisms of the Central Effects of Caffeine and Their Implications for Neuropsychiatric Disorders. J Caffeine Adenosine Res 8:121-131
Delgado-Vélez, Manuel; Lasalde-Dominicci, José A (2018) The Cholinergic Anti-Inflammatory Response and the Role of Macrophages in HIV-Induced Inflammation. Int J Mol Sci 19:
Rivera-Oliver, Marla; Moreno, Estefanía; Álvarez-Bagnarol, Yocasta et al. (2018) Adenosine A1-Dopamine D1 Receptor Heteromers Control the Excitability of the Spinal Motoneuron. Mol Neurobiol :
Capó-Vélez, Coral M; Delgado-Vélez, Manuel; Báez-Pagán, Carlos A et al. (2018) Nicotinic Acetylcholine Receptors in HIV: Possible Roles During HAND and Inflammation. Cell Mol Neurobiol :
Saxena, Manoj; Delgado, Yamixa; Sharma, Rohit Kumar et al. (2018) Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate. PLoS One 13:e0195542
Thapa, Bibek; Diaz-Diestra, Daysi; Santiago-Medina, Carlene et al. (2018) T1- and T2-weighted Magnetic Resonance Dual Contrast by Single Core Truncated Cubic Iron Oxide Nanoparticles with Abrupt Cellular Internalization and Immune Evasion. ACS Appl Bio Mater 1:79-89
Vaasjo, Lee O; Quintana, Alexandra M; Habib, Mohamed R et al. (2018) GABA-like immunoreactivity in Biomphalaria: Colocalization with tyrosine hydroxylase-like immunoreactivity in the feeding motor systems of panpulmonate snails. J Comp Neurol 526:1790-1805
Capó-Vélez, Coral M; Morales-Vargas, Bryan; García-González, Aurian et al. (2018) The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders. Sci Rep 8:1829
Colón, Jennifer M; González, Pablo A; Cajigas, Ámbar et al. (2018) Continuous tamoxifen delivery improves locomotor recovery 6h after spinal cord injury by neuronal and glial mechanisms in male rats. Exp Neurol 299:109-121
Alicea, Daniel; Perez, Marizabeth; Maldonado, Carolina et al. (2017) Cortactin Is a Regulator of Activity-Dependent Synaptic Plasticity Controlled by Wingless. J Neurosci 37:2203-2215

Showing the most recent 10 out of 82 publications