The Histology and Imaging Core will provide technical expertise, training, and state-of-the-art instrumentation for the processing of tissue and the analysis of biological samples, including confocal microscopy and stereology. In the previous submission, we did not have a Director for the Histology and Imaging Core and instead proposed to recruit a senior level scientist who could lead this Core. We have been successful in this recruitment effort with the addition of Dr Geoffrey Bove, a pain researcher with a primary focus on examining how inflammation affects primary afferent nociceptive neurons. Dr Bove has extensive experience in histology, image acquisition, histomorphology of neural and musculoskeletal structures, and immunofluorescent morphometry. He has published numerous manuscripts using histological and immunohistological methods, as well as using electron microscopy. Dr Bove has also developed immunoquantification methods using stereological and non-stereologicat approaches. In addition, we have recruited Dr Willis, a COBRE Project Leader with expertise in confocal and electron microscopy who will serve as co-Director The Histology and Imaging Core Directors will advise investigators on the best approach to address their questions, provide training in methodology and instrumentation, and to supervise the Core manager/technician.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
1P20GM103643-01A1
Application #
8466101
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
Project End
Budget Start
2012-08-15
Budget End
2013-05-31
Support Year
1
Fiscal Year
2012
Total Cost
$432,497
Indirect Cost
$42,567
Name
University of New England
Department
Type
DUNS #
071735252
City
Biddeford
State
ME
Country
United States
Zip Code
04005
Govea, Rosann M; Barbe, Mary F; Bove, Geoffrey M (2017) Group IV nociceptors develop axonal chemical sensitivity during neuritis and following treatment of the sciatic nerve with vinblastine. J Neurophysiol 118:2103-2109
Lei, Wei; Mullen, Nathan; McCarthy, Sarah et al. (2017) Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain. J Biol Chem 292:10414-10428
Havelin, Joshua; Imbert, Ian; Sukhtankar, Devki et al. (2017) Mediation of Movement-Induced Breakthrough Cancer Pain by IB4-Binding Nociceptors in Rats. J Neurosci 37:5111-5122
Follansbee, Taylor L; Gjelsvik, Kayla J; Brann, Courtney L et al. (2017) Drosophila Nociceptive Sensitization Requires BMP Signaling via the Canonical SMAD Pathway. J Neurosci 37:8524-8533
Cormier, Jim; Cone, Katherine; Lanpher, Janell et al. (2017) Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis. Life Sci 180:51-59
Allen, Joshua; Imbert, Ian; Havelin, Joshua et al. (2017) Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats. Arthritis Rheumatol 69:1407-1417
McLane, Virginia D; Bergquist, Ivy; Cormier, James et al. (2017) Long-term morphine delivery via slow release morphine pellets or osmotic pumps: Plasma concentration, analgesia, and naloxone-precipitated withdrawal. Life Sci 185:1-7
Harasawa, Ichiro; Johansen, Joshua P; Fields, Howard L et al. (2016) Alterations in the rostral ventromedial medulla after the selective ablation of ?-opioid receptor expressing neurons. Pain 157:166-73
Havelin, Joshua; Imbert, Ian; Cormier, Jennifer et al. (2016) Central Sensitization and Neuropathic Features of Ongoing Pain in a Rat Model of Advanced Osteoarthritis. J Pain 17:374-82
Malon, Jennifer T; Cao, Ling (2016) Preparation of Primary Mixed Glial Cultures from Adult Mouse Spinal Cord Tissue. J Vis Exp :

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