The Histology and Imaging Core will provide technical expertise, training, and state-of-the-art instrumentation for the processing of tissue and the analysis of biological samples, including confocal microscopy and stereology. In the previous submission, we did not have a Director for the Histology and Imaging Core and instead proposed to recruit a senior level scientist who could lead this Core. We have been successful in this recruitment effort with the addition of Dr Geoffrey Bove, a pain researcher with a primary focus on examining how inflammation affects primary afferent nociceptive neurons. Dr Bove has extensive experience in histology, image acquisition, histomorphology of neural and musculoskeletal structures, and immunofluorescent morphometry. He has published numerous manuscripts using histological and immunohistological methods, as well as using electron microscopy. Dr Bove has also developed immunoquantification methods using stereological and non-stereologicat approaches. In addition, we have recruited Dr Willis, a COBRE Project Leader with expertise in confocal and electron microscopy who will serve as co-Director The Histology and Imaging Core Directors will advise investigators on the best approach to address their questions, provide training in methodology and instrumentation, and to supervise the Core manager/technician.
|McLane, Virginia D; Cao, Ling; Willis, Colin L (2014) Morphine increases hippocampal viral load and suppresses frontal lobe CCL5 expression in the LP-BM5 AIDS model. J Neuroimmunol 269:44-51|
|Camire, Ryan B; Beaulac, Holly J; Brule, Stephanie A et al. (2014) Biphasic modulation of paracellular claudin-5 expression in mouse brain endothelial cells is mediated through the phosphoinositide-3-kinase/AKT pathway. J Pharmacol Exp Ther 351:654-62|
|Li, Yingxue; St Louis, Lindsay; Knapp, Brian I et al. (2014) Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to ?-endorphin? J Med Chem 57:2237-46|
|Burman, Michael A; Simmons, Cassandra A; Hughes, Miles et al. (2014) Developing and validating trace fear conditioning protocols in C57BL/6 mice. J Neurosci Methods 222:111-7|
|Meng, Ian D; Kurose, Masayuki (2013) The role of corneal afferent neurons in regulating tears under normal and dry eye conditions. Exp Eye Res 117:79-87|
|Wang, Yong; Lin, Lu; Lai, Helen et al. (2013) Transcription factor Sox11 is essential for both embryonic and adult neurogenesis. Dev Dyn 242:638-53|