This project will investigate the systems-level mechanisms of reinforcement learning as applied towards attention and visual-motor associative learning. We will use cross-areal neuronal recordings as well as combined cortical and subcortical stimulation in awake, behaving macaques to study prefrontal-striatal interactions during learning, and to drive attention and learning. We will record simultaneously in the lateral prefrontal cortex and striatum while animals perform an online learning task, to characterize learning-related changes in their correlated activity. We predict that learning will modify the magnitude or nature of these interactions. Furthermore, we will attempt to drive visual-spatial attention and visual-motor associative learning through the application of microstimulation to the frontal eye fields and to the dopamine-neuron containing regions of the midbrain. We predict that such combined stimulation will synergistically potentiate neural responses in the striatum, and will produce learned ("programmed") biases in attention and visualmotor behavior.

Public Health Relevance

The frontal cortex-basal ganglia system is centrally implicated in diseases ranging from movement disorders (e.g., Parkinson's Disease), to psychiatric diseases, (e.g., depression and obsessive-compulsive disorder). Also, many motor and cognitive deficits resulting from stroke or trauma are attributable to damage within this system. A better understanding of how learning occurs through neural interactions across these structures will allow us to better characterize the underlying derangements of neural processing in disease states and to develop ways to augment functional recovery.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103645-02
Application #
8721449
Study Section
Special Emphasis Panel (ZGM1-TWD-B)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
2
Fiscal Year
2014
Total Cost
$277,600
Indirect Cost
$58,134
Name
Brown University
Department
Type
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
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Im, Hee Yeon; Bédard, Patrick; Song, Joo-Hyun (2016) Long lasting attentional-context dependent visuomotor memory. J Exp Psychol Hum Percept Perform 42:1269-74
Moher, Jeff; Song, Joo-Hyun (2016) Target selection biases from recent experience transfer across effectors. Atten Percept Psychophys 78:415-26
McCarthy, J Daniel; Song, Joo-Hyun (2016) Global attention facilitates the planning, but not execution of goal-directed reaches. J Vis 16:7
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Markant, Julie; Ackerman, Laura K; Nussenbaum, Kate et al. (2016) Selective attention neutralizes the adverse effects of low socioeconomic status on memory in 9-month-old infants. Dev Cogn Neurosci 18:26-33
Markant, Julie; Amso, Dima (2016) The Development of Selective Attention Orienting is an Agent of Change in Learning and Memory Efficacy. Infancy 21:154-176
Nussenbaum, Kate; Amso, Dima (2016) An Attentional Goldilocks Effect: An Optimal Amount of Social Interactivity Promotes Word Learning from Video. J Cogn Dev 17:30-40
Markant, Julie; Oakes, Lisa M; Amso, Dima (2016) Visual selective attention biases contribute to the other-race effect among 9-month-old infants. Dev Psychobiol 58:355-65
Salminen, Lauren E; Schofield, Peter R; Pierce, Kerrie D et al. (2016) Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: A comprehensive assessment of white matter integrity and cognition. Behav Brain Res 296:85-93

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