Access to modern instrumentation is critical to the success of this COBRE. Investigators at MSU have been quite successful in obtaining shared major research instrumentation grants (primarily NSF) to obtain state-of the- art equipment needed for life and materials science research (1-6). Specifically, the P.l. and co-Is for this COBRE have received awards to purchase cell sorting, imaging and analysis tools to meet the needs of our biomedical research faculty. At present, the relatively small size of the biomedical research enterprise at MSU does not utilize the full capacity of several of these particular instruments or of the technical staff who operate them. We expect this situation to change as biomedical research grows at MSU and biomedical research faculty become more competitive: That growth will allow COBRE funding to be offset with user fees to help sustain these operations. By funding several new users, their laboratory staff and collaborators, and the acquisition of preliminary data leading to competitive funding, this COBRE will significantly augment the income of these facilities, allowing more efficient and timely replacements/upgrades of equipment thus allowing our investigators to be competitive with investigators at larger institutions. Components of this model have been successfully implemented, resulting in research faculty success and research institute growth at MSU (e.g. Institute for Imaging &Analytical Technologies, Institute for Genomics, Biotechnology &Biocomputing). From a COBRE sustainability perspective to promote """"""""collaborative interactive efforts among researchers with complementary backgrounds, skills and expertise and to compete independently for external peer-reviewed center or program project grant support"""""""", Core C is significant as it provides a successful model to do so in the MSU environment. Taking advantage of the long successful history of a productive service center with a successful business model will ensure that resources are available for the COBRE Junior Investigators to develop the thematic multidisciplinary research focus of this COBRE proposal into a research center.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-TWD-A (CB))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mississippi State University
Mississippi State
United States
Zip Code
Wilson, Gillian J; Tuffs, Stephen W; Wee, Bryan A et al. (2018) Bovine Staphylococcus aureus Superantigens Stimulate the Entire T Cell Repertoire of Cattle. Infect Immun 86:
Hui, Winnie W; Hercik, Kamil; Belsare, Sayali et al. (2018) Salmonella enterica Serovar Typhimurium Alters the Extracellular Proteome of Macrophages and Leads to the Production of Proinflammatory Exosomes. Infect Immun 86:
Lee, Juyeun; Park, Nogi; Park, Joo Youn et al. (2018) Induction of Immunosuppressive CD8+CD25+FOXP3+ Regulatory T Cells by Suboptimal Stimulation with Staphylococcal Enterotoxin C1. J Immunol 200:669-680
Nakamya, Mary F; Ayoola, Moses B; Park, Seongbin et al. (2018) The Role of Cadaverine Synthesis on Pneumococcal Capsule and Protein Expression. Med Sci (Basel) 6:
Wen, Feng; Li, Lei; Zhao, Nan et al. (2018) A Y161F Hemagglutinin Substitution Increases Thermostability and Improves Yields of 2009 H1N1 Influenza A Virus in Cells. J Virol 92:
Kaplan, Barbara L F (2018) Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis. Curr Protoc Toxicol 75:11.25.1-11.25.22
Wen, Feng; Blackmon, Sherry; Olivier, Alicia K et al. (2018) Mutation W222L at the Receptor Binding Site of Hemagglutinin Could Facilitate Viral Adaption from Equine Influenza A(H3N8) Virus to Dogs. J Virol 92:
Varela-Stokes, A S; Park, S H; Stokes, J V et al. (2018) Tick microbial communities within enriched extracts of Amblyomma maculatum. Ticks Tick Borne Dis 9:798-805
Lee, Jung Keun; Stokes, John V; Moraru, Gail M et al. (2018) Transmission of Amblyomma maculatum-Associated Rickettsia spp. During Cofeeding on Cattle. Vector Borne Zoonotic Dis 18:511-518
Ammari, Mais; McCarthy, Fiona; Nanduri, Bindu (2018) Leveraging Experimental Details for an Improved Understanding of Host-Pathogen Interactome. Curr Protoc Bioinformatics 61:8.26.1-8.26.12

Showing the most recent 10 out of 57 publications