Behavioral and neural investigations of spatiotemporal form integration in healthy and brain-injured persons In order to survive in a worid full of potentially life-threatening danger, the movement of objects in the visual scene must be rapidly detected and identified. Characterizing how the visual system constructs our perception of an object's form and motion is essential to understating how the visual system works in general. An understanding ofthe intact, normally functioning visual system is a fundamental starting place for diagnosing and treating the visual system when it is impaired or damaged. This proposal builds off of a growing body of evidence that our perception of a moving object is mediated by mutually interacting neural representations ofthe object's form and motion. This proposal investigates one unifying neural mechanism that may underiie such form-motion interactions: spatiotemporal form integration. Spatiotemporal form integration is the integration of neural representations of form features (i.e. the corners of an square) over space and time. The overall aim of this proposal is to investigate the properties and neural correlates of spatiotemporal form integration in mediating both form and motion perception and the possible application of this knowledge to the detection and identification of impaired neural processing in the visual system.
Specific aims 1 and 2 will investigate the roles and neural correlates of spatiotempoiral form integration in mediating form and motion perception.
Specific aim 3 will test the potential application of spatiotemporal form integration to serve as a metric dagnostic tool for detecting and identifying subtle neural damage and corresponding visual deficits. The project will take full advantage ofthe proposed Magnetic resonance imaging and Brain-lesioned patient database cores as well as the existing Nevada INBRE Bioinformatics core.

Public Health Relevance

This project may reveal and quantify poorly understood characteristics of visual perception that are important for how we perceive and experience the worid around us. The proposed research has the potential to provde a framework for detecting visual deficits and associated neurological damage.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103650-03
Application #
8681481
Study Section
Special Emphasis Panel (ZRR1-RI-4)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
$173,869
Indirect Cost
$48,608
Name
University of Nevada Reno
Department
Type
DUNS #
146515460
City
Reno
State
NV
Country
United States
Zip Code
89557
Chen, Wenfeng; Werdann, Michelle; Zhang, Yong (2018) The auxin-inducible degradation system enables conditional PERIOD protein depletion in the nervous system of Drosophila melanogaster. FEBS J 285:4378-4393
Cooper, Daphne A; Cortés-López, Mariela; Miura, Pedro (2018) Genome-Wide circRNA Profiling from RNA-seq Data. Methods Mol Biol 1724:27-41
Alaasam, Valentina J; Duncan, Richard; Casagrande, Stefania et al. (2018) Light at night disrupts nocturnal rest and elevates glucocorticoids at cool color temperatures. J Exp Zool A Ecol Integr Physiol 329:465-472
Ouyang, Jenny Q; Davies, Scott; Dominoni, Davide (2018) Hormonally mediated effects of artificial light at night on behavior and fitness: linking endocrine mechanisms with function. J Exp Biol 221:
Gwinn, O Scott; Matera, Courtney N; O'Neil, Sean F et al. (2018) Asymmetric neural responses for facial expressions and anti-expressions. Neuropsychologia 119:405-416
Knupp, David; Miura, Pedro (2018) CircRNA accumulation: A new hallmark of aging? Mech Ageing Dev 173:71-79
Zaeimian, Masoumeh Saber; Gallian, Brandon; Harrison, Clay et al. (2018) Mn Doped AZIS/ZnS Nanocrystals (NCs): Effects of Ag and Mn Levels on NC Optical Properties. J Alloys Compd 765:236-244
Xue, Yongbo; Zhang, Yong (2018) Emerging roles for microRNA in the regulation of Drosophila circadian clock. BMC Neurosci 19:1
Du, Juan; Zhang, Yifan; Xue, Yongbo et al. (2018) Diurnal protein oscillation profiles in Drosophila head. FEBS Lett 592:3736-3749
Retter, Talia L; Jiang, Fang; Webster, Michael A et al. (2018) Dissociable effects of inter-stimulus interval and presentation duration on rapid face categorization. Vision Res 145:11-20

Showing the most recent 10 out of 94 publications