The overall objective of the Cardiopulmonary Vascular Biology COBRE is to bring together a group of investigators in the fields of pulmonary and cardiovascular diseases in a unique trans-disciplinary approach to improve understanding of the pathogenesis and treatment of vascular pathobiology in lung and heart diseases.
The Specific Aims of this proposal are: l. Unite a group of multidisciplinary investigators in studies f vascular injury and repair in the pathogenesis of lung and heart injury. 2. Provide research support, protected time, and mentoring to enable junior investigators to attain independent research support in an """"""""incubator"""""""" environment, coupled with a robust program for the nurturing of career development and attainment of additional research skills. 3. Identify and support pilot investigators who will be funded to obtain preliminary data for research grants. 4. Support junior and pilot investigators through mentoring and support from the Cores. 5. Establish the basis for multidisciplinary program project grant(s) for research in vascular injury and repair. We propose a Center that includes 5 junior investigators and 1-2 pilot investigators, supported by Administrative and Cell Isolation/Organ Function Cores. Junior and pilot investigators will be mentored by accomplished scientists with a strong focus on career development. A unique feature of the Cardiopulmonary Vascular Biology COBRE is the melding under a common theme of vascular biology of research done by collaborating MDs, PhDs, and MD/PhDs. An outstanding group of scientists on the External Advisory Committee will provide advice, oversight, and critique. The Center will be administered by the Ocean State Research Institute, a non-profit research and education foundation located at the Providence VA Medical Center. The junior investigators and mentors are faculty at Alpert Medical School of Brown University, and they are employed by the Providence VAMC, Rhode Island Hospital, or Brown University. Generous and sustained institutional support has been provided for this COBRE. This innovative and multidisciplinary Cardiopulmonary Vascular Biology COBRE will provide an environment that fosters creative and trans-disciplinary approaches to study of pathobiology of vascular components of lung and cardiovascular diseases. As the Center develops, the COBRE will be broadened to include other components of the vascular wall. By bringing together both basic and clinical scientists from cardiovascular and pulmonary backgrounds into a vascular biology center, this COBRE will enhance understanding of pathogenesis and treatment of vascular diseases and enhance research of these diseases, prevalent in RI.

Public Health Relevance

Cardiovascular and lung vascular diseases are important causes of morbidity and mortality in the US. A multidisciplinary group of MD, PhD, and MD/PhD investigators will develop a research center focusing on understanding the biology of vascular injury. Improved understanding of mechanisms of blood vessel injury promotes development of new and innovative treatments. This Vascular Biology COBRE will be first of its kind in Rhode Island, a state with a high burden of both heart and lung disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103652-02
Application #
8735959
Study Section
Special Emphasis Panel (ZGM1-TWD-B (CB))
Program Officer
Liu, Yanping
Project Start
2013-09-20
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$2,039,892
Indirect Cost
$80,793
Name
Ocean State Research Institute, Inc.
Department
Type
DUNS #
848476271
City
Providence
State
RI
Country
United States
Zip Code
02908
Chambers, Eboni; Rounds, Sharon; Lu, Qing (2018) Pulmonary Endothelial Cell Apoptosis in Emphysema and Acute Lung Injury. Adv Anat Embryol Cell Biol 228:63-86
Sellke, Nicholas; Kuczmarski, Alex; Lawandy, Isabella et al. (2018) Enhanced coronary arteriolar contraction to vasopressin in patients with diabetes after cardiac surgery. J Thorac Cardiovasc Surg 156:2098-2107
Fallon, Eleanor A; Biron-Girard, Bethany M; Chung, Chun-Shiang et al. (2018) A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis. J Leukoc Biol :
Aldosari, Sarah; Awad, Maan; Harrington, Elizabeth O et al. (2018) Subcellular Reactive Oxygen Species (ROS) in Cardiovascular Pathophysiology. Antioxidants (Basel) 7:
Liu, Yuhong; Cole, Victoria; Lawandy, Isabella et al. (2018) Decreased coronary arteriolar response to KCa channel opener after cardioplegic arrest in diabetic patients. Mol Cell Biochem 445:187-194
Chorzalska, Anna; Ahsan, Nagib; Rao, R Shyama Prasad et al. (2018) Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-?B pathways in a model of chronic myeloid leukemia. Mol Oncol 12:630-647
Abbasi, Adeel; Devers, Cynthia; Muratore, Christopher S et al. (2018) Examining the role of extracorporeal membrane oxygenation in patients following suspected or confirmed suicide attempts: A case series. J Crit Care 44:445-449
Lu, Qing; Gottlieb, Eric; Rounds, Sharon (2018) Effects of cigarette smoke on pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol 314:L743-L756
Dennery, Phyllis A; Carr, Jennifer; Peterson, Abigail et al. (2018) THE ROLE OF MITOCHONDRIAL FATTY ACID USE IN NEONATAL LUNG INJURY AND REPAIR. Trans Am Clin Climatol Assoc 129:195-201
Banerjee, Debasree; Monaghan, Sean; Zhao, Runping et al. (2018) Soluble programmed cell death protein-1 and programmed cell death ligand-1 in sepsis. Crit Care 22:146

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