Major goals of this COBRE are to create resources that support highly talented faculty members and to facilitate collaborafion with clinicians. A further objective is to create a Screening, Analysis and Synthesis (SAS) Research Core that facilitates high throughput synthesis and rapid purificafion of molecular libraries. The success of young faculty at the University of Delaware has created a need to modernize space for research. Four ofthe COBRE researchers have research labs in the Department of Chemistry and Biochemistry (CBC) at UD. While CBC occupies more than 50,000 sq. ft. of research space, the space is more than 97% occupied. We propose to convert an anfiquated (40 year old) undergraduate teaching lab in 064 Drake Hall into a modern research laboratory. This renovation project will create over 1455 sq. ft. of state- of-the-art research space and associated offices to support the COBRE research effort. One purpose ofthe 1455 sq. ft. of renovated laboratory space in 064 Drake Hall is to meet the rapidly growing research space needs ofthe Leimkuhler Grimes group (subproject 1), which currently consists of 8 graduate students, 1 postdoctoral researcher, and 5 undergraduates. Currently, the Leimkuhler Grimes group occupies a nearby 1100 sq. ft laboratory. It is in this newly renovated lab space that the MD fellows from Nemours will conduct collaborative research with Grimes to identify biomarkers associated with Crohn's disease, which will be directly translated back to their clinical research setting at Nemours. The new space in 064 Drake Hall will also be used to house core instrumentafion for the production of the carbohydrate microarrays and core instrumentafion for compound library and microarray storage. The architectural drawings designate a 35'wide """"""""equipment zone"""""""" where this instrumentafion will be housed.

Public Health Relevance

The medicinal field is currently limited by the ability to discover new classes of molecules that can probe and treat human disease. The proposed work will have impact on discovery of molecules that can be used to study and treat a number of diseases, including cancer, Crohn's disease, Hunfington's disease, Alzheimer's disease, and Creutzfeldt-Jakob disease.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
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Special Emphasis Panel (ZGM1)
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University of Delaware
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Cinderella, Andrew P; Vulovic, Bojan; Watson, Donald A (2017) Palladium-Catalyzed Cross-Coupling of Silyl Electrophiles with Alkylzinc Halides: A Silyl-Negishi Reaction. J Am Chem Soc 139:7741-7744
Cobb, Kelsey M; Rabb-Lynch, Javon M; Hoerrner, Megan E et al. (2017) Stereospecific, Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling of Allylic Pivalates To Deliver Quaternary Stereocenters. Org Lett 19:4355-4358
Lambert, William D; Scinto, Samuel L; Dmitrenko, Olga et al. (2017) Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling. Org Biomol Chem 15:6640-6644
Vulovic, Bojan; Watson, Donald A (2017) Heck-like Reactions Involving Heteroatomic Electrophiles. European J Org Chem 2017:4996-5009
Guo, Chen; Kim, Heejae; Ovadia, Elisa M et al. (2017) Bio-orthogonal conjugation and enzymatically triggered release of proteins within multi-layered hydrogels. Acta Biomater 56:80-90
Rezazadeh, Sina; Devannah, Vijayarajan; Watson, Donald A (2017) Nickel-Catalyzed C-Alkylation of Nitroalkanes with Unactivated Alkyl Iodides. J Am Chem Soc 139:8110-8113
Urello, Morgan A; Kiick, Kristi L; Sullivan, Millicent O (2017) ECM turnover-stimulated gene delivery through collagen-mimetic peptide-plasmid integration in collagen. Acta Biomater 62:167-178
Wolfe, Aaron J; Si, Wei; Zhang, Zhengqi et al. (2017) Quantification of Membrane Protein-Detergent Complex Interactions. J Phys Chem B 121:10228-10241
Basch, Corey H; Liao, Jennie; Xu, Jianyu et al. (2017) Harnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C-N Bond Activation. J Am Chem Soc 139:5313-5316
Gietter-Burch, Amber A S; Devannah, Vijayarajan; Watson, Donald A (2017) Trifluoromethylation of Secondary Nitroalkanes. Org Lett 19:2957-2960

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