Infectious diseases continue to represent major causes of death and disease worldwide. Our strategy to address the challenge of new and emerging infectious diseases is to build a critical mass of investigators in infectious diseases immunology, committed to collaboration and innovation. The overall objective of this COBRE, """"""""Immune-Based Interventions against Infectious Diseases,"""""""" is to advance the development of a multidisciplinary and trans-institutional research program in infectious diseases of global importance. The unifying scientific theme of the COBRE is translational research at the interface of the pathogen and host. This COBRE represents a partnership between the Institute for Immunology and Informatics (I Cubed) at the University of Rhode Island's Providence campus, and the Center for International Health Research (CIHR) at Rhode Island Hospital. Both groups have established NIH-funded research programs in infectious diseases, immunology, and global health;their shared interests and close proximity in Providence present an ideal opportunity to create a synergistic research team.
The Specific Aims of this COBRE are: 1. Establish an integrated research community to provide leadership in translational infectious diseases immunology research to the Rhode Island community. 2. Build infrastructure for immunology research through support for Research Cores in Statistics and Data Management, Cell Analysis and Sorting, and Luminex High-Throughput Analysis. 3. Recruit promising junior investigators and provide mentoring by established NIH-funded researchers. 4. Support a multidisciplinary research program led by junior investigators in translational infectious diseases immunology.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
1P20GM104317-01
Application #
8432209
Study Section
Special Emphasis Panel (ZGM1-TWD-A (CB))
Program Officer
Canto, Maria Teresa
Project Start
2013-09-01
Project End
2018-05-31
Budget Start
2013-09-01
Budget End
2014-05-31
Support Year
1
Fiscal Year
2013
Total Cost
$2,390,922
Indirect Cost
$537,685
Name
University of Rhode Island
Department
Anatomy/Cell Biology
Type
Schools of Earth Sciences/Natur
DUNS #
144017188
City
Kingston
State
RI
Country
United States
Zip Code
02881
Lohman-Payne, Barbara; Gabriel, Benjamin; Park, Sangshin et al. (2018) HIV-exposed uninfected infants: elevated cord blood Interleukin 8 (IL-8) is significantly associated with maternal HIV infection and systemic IL-8 in a Kenyan cohort. Clin Transl Med 7:26
Adam, Awadalkareem; Woda, Marcia; Kounlavouth, Sonia et al. (2018) Multiplexed FluoroSpot for the Analysis of Dengue Virus- and Zika Virus-Specific and Cross-Reactive Memory B Cells. J Immunol 201:3804-3814
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Li, Ming; Tucker, Lynne D; Asara, John M et al. (2016) Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication. J Clin Invest 126:3117-29
Nixon, Christian P (2016) Plasmodium falciparum gametocyte transit through the cutaneous microvasculature: A new target for malaria transmission blocking vaccines? Hum Vaccin Immunother 12:3189-3195

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