Infectious diseases continue to represent major causes of death and disease worldwide. Our strategy to address the challenge of new and emerging infectious diseases is to build a critical mass of investigators in infectious diseases immunology, committed to collaboration and innovation. The overall objective of this COBRE, """"""""Immune-Based Interventions against Infectious Diseases,"""""""" is to advance the development of a multidisciplinary and trans-institutional research program in infectious diseases of global importance. The unifying scientific theme of the COBRE is translational research at the interface of the pathogen and host. This COBRE represents a partnership between the Institute for Immunology and Informatics (I Cubed) at the University of Rhode Island's Providence campus, and the Center for International Health Research (CIHR) at Rhode Island Hospital. Both groups have established NIH-funded research programs in infectious diseases, immunology, and global health;their shared interests and close proximity in Providence present an ideal opportunity to create a synergistic research team.
The Specific Aims of this COBRE are: 1. Establish an integrated research community to provide leadership in translational infectious diseases immunology research to the Rhode Island community. 2. Build infrastructure for immunology research through support for Research Cores in Statistics and Data Management, Cell Analysis and Sorting, and Luminex High-Throughput Analysis. 3. Recruit promising junior investigators and provide mentoring by established NIH-funded researchers. 4. Support a multidisciplinary research program led by junior investigators in translational infectious diseases immunology.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Special Emphasis Panel (ZGM1-TWD-A (CB))
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Canto, Maria Teresa
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University of Rhode Island
Anatomy/Cell Biology
Schools of Earth Sciences/Natur
United States
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Lohman-Payne, Barbara; Gabriel, Benjamin; Park, Sangshin et al. (2018) HIV-exposed uninfected infants: elevated cord blood Interleukin 8 (IL-8) is significantly associated with maternal HIV infection and systemic IL-8 in a Kenyan cohort. Clin Transl Med 7:26
Adam, Awadalkareem; Woda, Marcia; Kounlavouth, Sonia et al. (2018) Multiplexed FluoroSpot for the Analysis of Dengue Virus- and Zika Virus-Specific and Cross-Reactive Memory B Cells. J Immunol 201:3804-3814
Nixon, Christian P; Satyagraha, Ari W; Baird, Grayson L et al. (2018) Accurate light microscopic diagnosis of South-East Asian ovalocytosis. Int J Lab Hematol 40:655-662
Cheruiyot, Collins; Pataki, Zemplen; Williams, Robert et al. (2017) SILAC Based Proteomic Characterization of Exosomes from HIV-1 Infected Cells. J Vis Exp :
Nixon, Christian P; Prsic, Elizabeth H; Guertin, Christine A et al. (2017) Acquired Factor XIII inhibitor associated with mantle cell lymphoma. Transfusion 57:694-699
Nixon, Christina E; Park, Sangshin; Pond-Tor, Sunthorn et al. (2017) Identification of Protective B-Cell Epitopes within the Novel Malaria Vaccine Candidate Plasmodium falciparum Schizont Egress Antigen 1. Clin Vaccine Immunol 24:
Barbier, Vincent; Lang, Diane; Valois, Sierra et al. (2017) Dengue virus induces mitochondrial elongation through impairment of Drp1-triggered mitochondrial fission. Virology 500:149-160
Smith, Andrew M; Papaleo, Cassandra; Reid, Christopher W et al. (2017) RNA-Seq reveals a central role for lectin, C1q and von Willebrand factor A domains in the defensive glue of a terrestrial slug. Biofouling 33:741-754
Li, Ming; Tucker, Lynne D; Asara, John M et al. (2016) Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication. J Clin Invest 126:3117-29
Nixon, Christian P (2016) Plasmodium falciparum gametocyte transit through the cutaneous microvasculature: A new target for malaria transmission blocking vaccines? Hum Vaccin Immunother 12:3189-3195

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