Robust regeneration of tissues and complex organs is the norm for countless invertebrate and nonmammalian vertebrate species. In addition, nature has endowed certain animals with remarkable longevity and robust tissue repair mechanisms that slow aging-induced degenerative processes, or with increased susceptibility to cellular and molecular damage and concomitantly short lifespans. Numerous fundamental questions in regenerative biology can only be answered in vivo using diverse non-mammalian animal models. In addition, comparative studies of diverse organisms provide deeper mechanistic insights that are not possible using a single model or """"""""model-centric"""""""" approach, and they can speed the pace and reduce the cost of biomedical discovery. The Comparative Animal Models Core builds on MDIBL's unique strength and expertise in comparative animal biology and will provide COBRE investigators with resources necessary to utilize diverse animal models in regenerative and aging biology research. For the current application, the Core focuses primarily on providing resources and services to COBRE Project Leaders for their proposed zebrafish studies. These resources include day-to-day husbandry, importation and quarantine services, spawning services to produce embryos for experimental studies, microinjection and surgical services, drug treatment services and genotyping using visual inspection and PCR-based methods. The Core will also have both the facilities and expertise necessary to provide COBRE associated investigators as well as potential new COBRE Project Leaders with resources for other vertebrate and invertebrate model systems useful in regenerative and aging biology research including C. elegans, amphibians and various fish species. Our long term goal is to develop the Core into a one-of-a-kind animal resource by leveraging the scientific background and expertise of the Core Director, his staff and MDIBL's faculty, as well as MDIBL's 113-year history of providing and maintaining diverse marine organisms for biomedical research. The Comparative Animal Models Core will thus contribute not only to the success and long term sustainability of the COBRE, but also to the success and continued growth of MDIBL and biomedical research in Maine.

Public Health Relevance

Numerous fundamental questions in regenerative biology can only be answered in vivo using diverse non mammalian animal models. Non-mammalian animal studies also speed the pace and reduce the cost of biomedical discovery. The Comparative Animal Models Core provides comprehensive resources required for the use of diverse non-mammalian model organisms in regenerative biology and medicine research.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Special Emphasis Panel (ZGM1-TWD-B (CB))
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Mount Desert Island Biological Lab
Salsbury Cove
United States
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Lee, Bum-Kyu; Uprety, Nadima; Jang, Yu Jin et al. (2018) Fosl1 overexpression directly activates trophoblast-specific gene expression programs in embryonic stem cells. Stem Cell Res 26:95-102
Hampton, Thomas H; Jackson, Craig; Jung, Dawoon et al. (2018) Arsenic Reduces Gene Expression Response to Changing Salinity in Killifish. Environ Sci Technol 52:8811-8821
Yin, Viravuth P (2018) In Situ Detection of MicroRNA Expression with RNAscope Probes. Methods Mol Biol 1649:197-208
King, Benjamin L; Rosenstein, Michael C; Smith, Ashley M et al. (2018) RegenDbase: a comparative database of noncoding RNA regulation of tissue regeneration circuits across multiple taxa. NPJ Regen Med 3:10
Lavine, Kory J; Pinto, Alexander R; Epelman, Slava et al. (2018) The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4). J Am Coll Cardiol 72:2213-2230
Yamada, Toshiki; Strange, Kevin (2018) Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function. J Gen Physiol 150:1003-1015
Waldron, Ashley L; Schroder, Patricia A; Bourgon, Kelly L et al. (2018) Oxidative stress-dependent MMP-13 activity underlies glucose neurotoxicity. J Diabetes Complications 32:249-257
Beck, Samuel; Rhee, Catherine; Song, Jawon et al. (2018) Implications of CpG islands on chromosomal architectures and modes of global gene regulation. Nucleic Acids Res 46:4382-4391
Andralojc, Karolina M; Campbell, Anne C; Kelly, Ashley L et al. (2017) ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans. PLoS Genet 13:e1006611
Godwin, James W; Pinto, Alexander R; Rosenthal, Nadia A (2017) Chasing the recipe for a pro-regenerative immune system. Semin Cell Dev Biol 61:71-79

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