Regenerative medicine is the field of R&D and medical practice focused on repairing and replacing tissues and organs damaged by injury, disease and aging-associated degenerative changes. While most human tissues and organs have limited or no regenerative capacity, numerous diverse invertebrates and non- mammalian vertebrates readily repair and replace lost and damaged organs, including the heart, limbs, spinal cord and kidney, throughout their lives. Comparative studies of these animal models provide the opportunity to define the core cellular and molecular mechanisms underlying repair and regeneration processes. The ability to carry out research on regenerative processes in diverse animal models requires specialized facilities and expertise. The COBRE Comparative Animal Models (CAM) Core builds on MDIBL?s unique and increasingly important expertise in comparative animal biology to provide the animal resources necessary to grow and sustain the Kathryn Davis Center for Regenerative Biology and Medicine. During Phase I COBRE funding, the Core provided husbandry as well as associated specialized services such as embryo microinjection and transgenesis for multiple diverse animal models including zebrafish, Polypterus, medaka and C. elegans. The Core also provided the facilities and expertise needed to support the recruitment of two new Project Leaders using salamanders and Drosophila as model systems. Over the past four years, Core- supported research projects resulted in the publication of 26 papers by Phase I Project Leaders and 25 papers by non-COBRE faculty. This research in turn resulted in multiple firsts for the MDIBL including the discovery of three lead small molecules for regenerative medicine applications, six U.S. and international patent applications, one issued U.S. patent and the launch of the spinoff company Novo Biosciences. The overarching goal of the CAM Core is to support the research programs of COBRE Phase II Project Leaders and other investigators in the Davis Center and to help ensure the Center?s long-term sustainability. This will be accomplished by 1) providing Project Leaders and Davis Center faculty with animal husbandry resources as well as specialized experimental services, 2) establishing authentication services for genetic animal models and cell lines, and 3) expanding user fee-supported services to ensure long-term Core sustainability.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM104318-07
Application #
9723134
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2019-06-01
Budget End
2020-05-31
Support Year
7
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Mount Desert Island Biological Lab
Department
Type
DUNS #
077470003
City
Salsbury Cove
State
ME
Country
United States
Zip Code
04672
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Hampton, Thomas H; Jackson, Craig; Jung, Dawoon et al. (2018) Arsenic Reduces Gene Expression Response to Changing Salinity in Killifish. Environ Sci Technol 52:8811-8821
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Lavine, Kory J; Pinto, Alexander R; Epelman, Slava et al. (2018) The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4). J Am Coll Cardiol 72:2213-2230
Yamada, Toshiki; Strange, Kevin (2018) Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function. J Gen Physiol 150:1003-1015
Waldron, Ashley L; Schroder, Patricia A; Bourgon, Kelly L et al. (2018) Oxidative stress-dependent MMP-13 activity underlies glucose neurotoxicity. J Diabetes Complications 32:249-257
Beck, Samuel; Rhee, Catherine; Song, Jawon et al. (2018) Implications of CpG islands on chromosomal architectures and modes of global gene regulation. Nucleic Acids Res 46:4382-4391
Andralojc, Karolina M; Campbell, Anne C; Kelly, Ashley L et al. (2017) ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans. PLoS Genet 13:e1006611
Godwin, James W; Pinto, Alexander R; Rosenthal, Nadia A (2017) Chasing the recipe for a pro-regenerative immune system. Semin Cell Dev Biol 61:71-79

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