Cardiovascular, renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the United States, especially in Mississippi which has the highest prevalence in the nation of these diseases. These disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes, are major causes of cardiovascular and renal disease. Abnormal kidney function is an important cause as well as a consequence of hypertension, a key risk factor for cardiovascular diseases such coronary artery disease and stroke. Understanding the complex relationships among cardiovascular, renal, and metabolic disorders and developing new therapeutic approaches requires a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major objective of this proposal is to develop an internationally recognized Cardiorenal and Metabolic Diseases Research Center (CMDRC) that brings together a multidisciplinary group of basic, clinical and population scientists working on a common synergistic theme, and to facilitate their collaborations.
The specific aims are: 1) To develop infrastructure and core facilities that foster excellence in basic, clinical, and population research in cardiorenal and metabolic diseases and increase competitiveness of junior investigators for independent funding from NIH and other national biomedical research programs.;2) To develop mentoring and education programs and research support for promising junior investigators so that they can become productive, independent investigators who can successfully compete for NIH funding;3) To achieve the specific aims of the research projects described by the junior investigators in this proposal, and to foster their career development;4) To develop a pipeline of diverse predoctoral graduate students, medical students and postdoctoral fellows trained in cutting edge cardiorenal and metabolic diseases research so they become the next generation of researchers in this field;major emphasis will be placed on recruiting and mentoring underrepresented minority investigators through partnerships with local minority institutions;5) To enhance collaborations and interactions among established investigators from multiple disciplines in cardiorenal and metabolic diseases at UMMC, as well as with external partners;6) To strengthen cardiorenal and metabolic disease research at UMMC by recruiting new faculty with expertise in clinical and translational research and in emerging technologies, such as in vivo imaging, molecular genetics, bioinformatics, and systems analysis.
Cardiorenal and metabolic diseases are the leading causes of mortality and morbidity in the United States, especially in Mississippi which has the highest prevalence in the nation of these diseases. This is a critical area for research development in Mississippi, especially in view of th emerging opportunities to develop a comprehensive, multidisciplinary research center at UMMC that focuses on these major causes of mortality and morbidity. This proposal represents a plan to develop a unique, internationally recognized COBRE that is dedicated to improving lives through research, discovery and innovation.
|Bassi, M; Nakamura, N B; Furuya, W I et al. (2015) Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function. Acta Physiol (Oxf) 213:893-901|
|Lu, Silu; Xiang, Lusha; Clemmer, John S et al. (2014) Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 channels. Microcirculation 21:754-60|
|Ma, Yonggang; Yabluchanskiy, Andriy; Lindsey, Merry L (2014) Heavy hitting: Using water to label humans. Proteomics Clin Appl 8:477-9|
|Alexander, Barbara T; Henry Dasinger, John; Intapad, Suttira (2014) Effect of low birth weight on women's health. Clin Ther 36:1913-23|
|DeLeon-Pennell, Kristine Y; de Castro Brás, Lisandra E; Iyer, Rugmani Padmanabhan et al. (2014) P. gingivalis lipopolysaccharide intensifies inflammation post-myocardial infarction through matrix metalloproteinase-9. J Mol Cell Cardiol 76:218-26|
|Hall, Michael E; do Carmo, Jussara M; da Silva, Alexandre A et al. (2014) Obesity, hypertension, and chronic kidney disease. Int J Nephrol Renovasc Dis 7:75-88|
|Hall, Michael E; Maready, Matthew W; Hall, John E et al. (2014) Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation. Am J Physiol Endocrinol Metab 307:E316-25|
|Chandrashekar, Kiran; Juncos, Luis A (2014) Endothelin antagonists in diabetic nephropathy: back to basics. J Am Soc Nephrol 25:869-71|
|George, Eric M; Garrett, Michael R; Granger, Joey P (2014) Placental ischemia induces changes in gene expression in chorionic tissue. Mamm Genome 25:253-61|
|Oguchi, Hideyo; Sasamura, Hiroyuki; Shinoda, Kazunobu et al. (2014) Renal arteriolar injury by salt intake contributes to salt memory for the development of hypertension. Hypertension 64:784-91|
Showing the most recent 10 out of 24 publications