Our objective is to establish a highly interactive and dynamic group of investigators whose research focuses on understanding the functional role of epigenetic changes in human disease etiology and progression. We have proposed five new research projects all led by junior investigators, that will use molecular, biochemical, and computational biology approaches to study epigenetic regulation in different disease models. We will help define the role that environmental stressors play in disruption of the epigenome, and propose cutting edge, critical research in trans-generational models to understand how changes in the epigenomic may be linked to complex inheritance patterns and familial risk factors for high incidence diseases. These goals will be accomplished utilizing an integrative, systems biology approach to link epigenomic platforms such as global methylation arrays with next-generation RNA-sequencing and Chip-sequencing. To enhance the program further, we have included a translational component as a key facet of this COBRE, which is consistent with our global, strategic mission to address the needs of North Dakota's aging, largely rural population. Because epigenetic changes are potentially reversible, we believe that this research could lead to new treatment paradigms for devastating diseases such as cancer, drug addiction, and cardiovascular disease. The rationale for this center is that each individual brings unique expertise and key directions that together can help elucidate the role of epigenetic changes in various disease models. This center will nurture a focused group of investigators, and successful completion of our specific aims will result in the establishment of a collaborative and sustainable Center of Excellence in the Epigenomics of Development and Disease capable of attracting the brightest and most talented faculty, graduate students and postdoctoral fellows to conduct world class research in the burgeoning field of epigenetics. UND is fully committed to ensuring the growth and sustainability of this group even after the COBRE grant ends.

Public Health Relevance

COBRE Phase I funding will (1) support five research projects that are initiated by young investigators, (2) centralized the bioinformatics core essential to our COBRE group as well as to other biomedical researchers, (3) support our administrative core that provides for a visiting speaker program, library acquisitions, an annual symposium/workshop and having an individualized mentoring program.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM104360-02
Application #
8732677
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Caldwell, Sheila
Project Start
2013-09-10
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of North Dakota
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Grand Forks
State
ND
Country
United States
Zip Code
58202
Dhasarathy, Archana; Roemmich, James N; Claycombe, Kate J (2017) Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes. Mol Aspects Med 54:37-49
Casselli, Timothy; Qureshi, Humaira; Peterson, Elizabeth et al. (2017) MicroRNA and mRNA Transcriptome Profiling in Primary Human Astrocytes Infected with Borrelia burgdorferi. PLoS One 12:e0170961
Challasivakanaka, Sathya; Zhen, Juan; Smith, Margaret E et al. (2017) Dopamine Transporter Phosphorylation Site Threonine 53 is Stimulated by Amphetamines and Regulates Dopamine Transport, Efflux, and Cocaine Analog Binding. J Biol Chem :
Simmler, Linda D; Anacker, Allison M J; Levin, Michael H et al. (2017) Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. Br J Pharmacol 174:2716-2738
Krout, Danielle; Rodriquez, Meghan; Brose, Stephen A et al. (2017) Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms. ACS Chem Neurosci 8:1011-1018
Scheidegger, Adam; Nechaev, Sergei (2016) RNA polymerase II pausing as a context-dependent reader of the genome. Biochem Cell Biol 94:82-92
Warns, Jessica A; Davie, James R; Dhasarathy, Archana (2016) Connecting the dots: chromatin and alternative splicing in EMT. Biochem Cell Biol 94:12-25
Schaar, Anne; Sukumaran, Pramod; Sun, Yuyang et al. (2016) TRPC1-STIM1 activation modulates transforming growth factor ?-induced epithelial-to-mesenchymal transition. Oncotarget 7:80554-80567
Zarns, Kristopher; Desell, Travis; Nechaev, Sergei et al. (2015) Searching the Human Genome for Snail and Slug With DNA@Home. Proc IEEE Int Conf Escience 2015:429-438
Karadeniz, ?lknur; Hur, Junguk; He, Yongqun et al. (2015) Literature Mining and Ontology based Analysis of Host-Brucella Gene-Gene Interaction Network. Front Microbiol 6:1386

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