We proposed to establish a sustainable Center of Biomedical Research Excellence (COBRE) in Molecular Epidemiology at Dartmouth structured to support the recruitment, career development, and engagement of talented junior investigators who will advance their research in molecular epidemiology as part of the new Center. We will bring together a diverse faculty with shared interests in integrating and translating cutting edge scientific technologies and discoveries to improve our understanding of major human health concerns, and ultimately inform clinical decision and practice change. Faculty will span multiple departments in Dartmouth Medical School, Dartmouth Hitchcock Medical Center, and the Dartmouth College of Arts and Sciences. Dartmouth Medical School has a long and distinguished tradition in epidemiology having conducted the first NIH funded chemoprevention trial of cancer in the early 1980s, and numerous population based studies to illuminate the pathogenesis of major health outcomes. Extending this tradition with strong support from Dartmouth will position us to serve as a vital resource in molecular epidemiology for northern New England and for COBRE and IDeA Networks of Biomedical Research Excellence (INBRE) programs nationally. To our knowledge, there are no other academic centers for molecular epidemiology in New England, or currently funded COBREs focused on molecular epidemiology nationally. As part of the proposed COBRE, we will supply the critical molecular epidemiology research infrastructure from which innovative methods can be applied and new discoveries can be translated. This will be achieved through four independent research projects with tightly interwoven themes along with a state-of-the-art, multidisciplinary Biorepository Core and vibrant Administrative, Career Development, and Research Integration Core. Building on the growing presence of molecular epidemiology in New Hampshire, we are poised to establish this new Center over the next five years with the goals of: 1) stimulating rigorous innovative research and fostering the career development of junior investigators and recruiting new faculty, 2) promoting translation of emerging technologies and basic research findings on common pathways of disease etiology and progression, and 3) informing strategies to prevent human disease throughout the lifespan.

Public Health Relevance

We propose to establish a new translational biomedical research center that will build upon Dartmouth's long tradition in epidemiology to foster investigations that apply cutting-edge innovations to illuminate the causes of human diseases. As such, the Center has the potential to change practice and reduce disease burden throughout the lifespan. Our proposed COBRE Center for Molecular Epidemiology at Dartmouth will provide a unique resource for the next generation of scientists and for COBRE/INBRE programs regionally and nationally.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-TWD-A (CB))
Program Officer
Liu, Yanping
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Dartmouth College
Family Medicine
Schools of Medicine
United States
Zip Code
Koestler, Devin C; Usset, Joseph; Christensen, Brock C et al. (2017) DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes. Cancer Epidemiol Biomarkers Prev 26:328-338
Demidenko, Eugene (2017) Exact and Approximate Statistical Inference for Nonlinear Regression and the Estimating Equation Approach. Scand Stat Theory Appl 44:636-665
Chen, Youdinghuan; Marotti, Jonathan D; Jenson, Erik G et al. (2017) Concordance of DNA methylation profiles between breast core biopsy and surgical excision specimens containing ductal carcinoma in situ (DCIS). Exp Mol Pathol 103:78-83
Titus, Alexander J; Way, Gregory P; Johnson, Kevin C et al. (2017) Deconvolution of DNA methylation identifies differentially methylated gene regions on 1p36 across breast cancer subtypes. Sci Rep 7:11594
Demidenko, Eugene; Glaholt, S P; Kyker-Snowman, E et al. (2017) Single toxin dose-response models revisited. Toxicol Appl Pharmacol 314:12-23
Fedirko, Veronika; McKeown-Eyssen, Gail; Serhan, Charles N et al. (2017) Plasma lipoxin A4 and resolvin D1 are not associated with reduced adenoma risk in a randomized trial of aspirin to prevent colon adenomas. Mol Carcinog 56:1977-1983
Patel, Chirag J; Kerr, Jacqueline; Thomas, Duncan C et al. (2017) Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies. Cancer Epidemiol Biomarkers Prev 26:1370-1380
Romano, Megan E; Kalloo, Geetika; Etzel, Taylor et al. (2017) Re: Seasonal Variation in Exposure to Endocrine-disrupting Chemicals. Epidemiology 28:e42-e43
Gilbert-Diamond, D; Emond, J A; Lansigan, R K et al. (2017) Television food advertisement exposure and FTO rs9939609 genotype in relation to excess consumption in children. Int J Obes (Lond) 41:23-29
Moyer, Benjamin J; Rojas, Itzel Y; Kerley-Hamilton, Joanna S et al. (2017) Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice. Nutr Res 44:38-50

Showing the most recent 10 out of 99 publications