The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) at The University of Mississippi School of Pharmacy (UM), initiated four years ago through a COBRE grant, has developed a multidisciplinary team committed to evaluating the effects of natural products on the central nervous system (CNS). The Center now has the potential to develop and sustain an innovative and independently funded research center focused on treating disorders associated with the nervous system. Faculty in the Center and its academic home, the School of Pharmacy, have already reported groundbreaking observations on the roles of cannabinoids and non-cannabinoids in the etiology of weight control, the control of the immune system, treatment of cancer, control of nausea and vomiting in patients receiving anti-neoplastic treatment, glaucoma, and the development of sigma receptor agonists in the treatment of cocaine and methamphetamine abuse. Also, CORE-NPN-supported investigators have increased their competitiveness by attracting extramural funds and publishing in leading journals of neuroscience. The Center will continue to provide an excellent environment for junior and mid-level investigators by working in close collaboration with leading national centers and scientists studying natural products to carry out the proposed projects that build on these novel insights into the pathophysiology of nervous system disorders. To achieve the goal of establishing an innovative and multidisciplinary Center focused on the use of natural products to manage neuropharmacologic disorders, the following Specific Aims are proposed:
Aim 1 is to enhance the competitive independent research funding of four investigators, as detailed in their research proposals. In addition, external and internal renowned scientists in natural products neuroscience will continue to mentor all Center faculty members in basic and clinical neuroscience.
Aim 2 is to sponsor a competitive small grant program that advances research in neuroscience related to the themes outlined in the proposal.
Aim 3 is to continue the expansion of research resources for the development of innovative natural product neuropharmacology - related projects. Core facilities to accomplish this will include: a) acquisition of novel plants and fungi and isolation of biologically active natural products, b) chemical elucidation of the biologically active secondary metabolites and synthesis of derivatives, c) in vitro assays to identify biologically active natural products, and d) in vivo assays to evaluate behavioral studies of the biologically active natural products.
Aim 4 is to continue faculty development and growth of new neuroscience investigators through training in cutting-edge technologies and to promote research opportunities in neuroscience for undergraduate and graduate students being mentored by Center faculty.
The focus on natural products in neuroscience and projects examining integrated models, along with outstanding Center faculty, training opportunities, a small grant program and generous support by the UM administration will ensure the continued growth of a research center that is innovative, multidisciplinary, and moving strongly toward independent funding, along with the development of a core of new and senior neuroscience faculty.
|Journigan, V Blair; Mésangeau, Christophe; Vyas, Neha et al. (2014) Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors. J Med Chem 57:8903-27|
|Maddineni, Sindhuri; Battu, Sunil Kumar; Morott, Joe et al. (2014) Formulation optimization of hot-melt extruded abuse deterrent pellet dosage form utilizing design of experiments. J Pharm Pharmacol 66:309-22|
|Chatterjee, Arindam; Cutler, Stephen J; Doerksen, Robert J et al. (2014) Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening. Bioorg Med Chem 22:6409-21|
|James, Michelle L; Shen, Bin; Nielsen, Carsten H et al. (2014) Evaluation of ýý-1 receptor radioligand 18F-FTC-146 in rats and squirrel monkeys using PET. J Nucl Med 55:147-53|
|Husni, Afeef S; McCurdy, Christopher R; Radwan, Mohamed M et al. (2014) Evaluation of Phytocannabinoids from High Potency Cannabis sativa using In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2. Med Chem Res 23:4295-4300|
|Tarawneh, Amer H; León, Francisco; Ibrahim, Mohammed A et al. (2014) Flavanones from Miconia prasina. Phytochem Lett 7:130-132|
|Tarawneh, Amer H; Leon, Francisco; Radwan, Mohamed M et al. (2013) Fatty acids with in vitro binding affinity for human opioid receptors from the fungus Emericella nidulans. J Agric Food Chem 61:10476-80|
|Hippalgaonkar, Ketan; Adelli, Goutham R; Hippalgaonkar, Kanchan et al. (2013) Indomethacin-loaded solid lipid nanoparticles for ocular delivery: development, characterization, and in vitro evaluation. J Ocul Pharmacol Ther 29:216-28|
|Wang, Xiaoning; Radwan, Mohamed M; Tarawneh, Amer H et al. (2013) Antifungal activity against plant pathogens of metabolites from the endophytic fungus Cladosporium cladosporioides. J Agric Food Chem 61:4551-5|
|Gao, Jiangtao; Radwan, Mohamed M; Leon, Francisco et al. (2013) Correction to Neocosmospora sp.-Derived Resorcylic Acid Lactones with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors. J Nat Prod 76:2174|
Showing the most recent 10 out of 14 publications