Abstract

The purpose of the Histology, Image Acquisition and Image Analysis Core is to provide to the PJIs and diabetes funded investigators, tissue processing, embedding, sectioning, histochemical and immune staining of mounted slides, quality state of the art instrumentation and expertise to obtain microscopic images with light, epifluorescent, and Nomarski optics;to provide software for morphometric analysis and to produce publication quality images. An online signup for image core equipment is available on the campus net. The Core personnel also educate and train Pi's, faculty, staff and students in the capabilities and proper use of the sophisticated equipment as well as in tissue processing.

Public Health Relevance

In order to investigate diabetes disease outcomes and treatment interventions in animal models it is necessary to be able to evaluate the histological structure of tissues, organs and organ systems. The Histology, Image Acquisition and Image Analysis Core provides this critical support to diabetes researchers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
9P20GM104934-06
Application #
8521817
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Project Start
Project End
Budget Start
2012-09-10
Budget End
2013-06-30
Support Year
6
Fiscal Year
2012
Total Cost
$146,408
Indirect Cost
$47,484

  Institution

Name
University of Oklahoma Health Sciences Center
Department
Type
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117

  Publications

Wang, Bing; Li, Pui-Kai; Ma, Jian-Xing et al. (2018) Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage. Invest Ophthalmol Vis Sci 59:3630-3642
Shin, Younghwa; Moiseyev, Gennadiy; Petrukhin, Konstantin et al. (2018) A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration. Biochim Biophys Acta Mol Basis Dis 1864:2420-2429
Fu, Shuhua; Dong, Shuqian; Zhu, Meili et al. (2018) VEGF as a Trophic Factor for Müller Glia in Hypoxic Retinal Diseases. Adv Exp Med Biol 1074:473-478
Orock, Albert; Logan, Sreemathi; Deak, Ferenc (2018) Munc18-1 haploinsufficiency impairs learning and memory by reduced synaptic vesicular release in a model of Ohtahara syndrome. Mol Cell Neurosci 88:33-42
Vadvalkar, Shraddha S; Matsuzaki, Satoshi; Eyster, Craig A et al. (2017) Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: ROLE OF MITOCHONDRIAL PYRUVATE CARRIER 2 (MPC2) ACETYLATION. J Biol Chem 292:4423-4433
He, Xuemin; Cheng, Rui; Park, Kyoungmin et al. (2017) Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway. Kidney Int 91:642-657
Deng, Guotao; Moran, Elizabeth P; Cheng, Rui et al. (2017) Therapeutic Effects of a Novel Agonist of Peroxisome Proliferator-Activated Receptor Alpha for the Treatment of Diabetic Retinopathy. Invest Ophthalmol Vis Sci 58:5030-5042
Du, Mei; Phelps, Eric; Balangue, Michael J et al. (2017) Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration. Invest Ophthalmol Vis Sci 58:4375–4383
Jung, Dongju; Xu, Yuechi; Sun, Zhongjie (2017) Induction of anti-aging gene klotho with a small chemical compound that demethylates CpG islands. Oncotarget 8:46745-46755
Shin, Younghwa; Moiseyev, Gennadiy; Chakraborty, Dibyendu et al. (2017) A Dominant Mutation in Rpe65, D477G, Delays Dark Adaptation and Disturbs the Visual Cycle in the Mutant Knock-In Mice. Am J Pathol 187:517-527

Showing the most recent 10 out of 101 publications