Public Health Relevance

This project investigates how a protein involved in the onset of type 2 diabetes functions at the molecular level. Through these studies we aim to gain insights into how the protien, called GRP78, functions in the diabetic state and determine if the protein is a viable target for new therapeutics in the future.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM104934-07
Application #
8542667
Study Section
Special Emphasis Panel (ZRR1-RI-B)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
7
Fiscal Year
2013
Total Cost
$208,348
Indirect Cost
$67,572
Name
University of Oklahoma Health Sciences Center
Department
Type
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Hu, Shuqun; Liu, Hua; Ha, Yonju et al. (2015) Posttranslational modification of Sirt6 activity by peroxynitrite. Free Radic Biol Med 79:176-85
McBride, Jeffrey D; Jenkins, Alicia J; Liu, Xiaochen et al. (2014) Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol 134:1725-34
Zhou, Kelu Kevin; Benyajati, Siribhinya; Le, Yun et al. (2014) Interruption of Wnt signaling in Müller cells ameliorates ischemia-induced retinal neovascularization. PLoS One 9:e108454
Moran, Elizabeth; Ding, Lexi; Wang, Zhongxiao et al. (2014) Protective and antioxidant effects of PPAR? in the ischemic retina. Invest Ophthalmol Vis Sci 55:4568-76
Fu, Shuhua; Zhu, Meili; Wang, Changyun et al. (2014) Efficient induction of productive Cre-mediated recombination in retinal pigment epithelium. Mol Vis 20:480-7
Takahashi, Yusuke; Moiseyev, Gennadiy; Ma, Jian-xing (2014) Identification of key residues determining isomerohydrolase activity of human RPE65. J Biol Chem 289:26743-51
Lee, Kyungwon; Shin, Younghwa; Cheng, Rui et al. (2014) Receptor heterodimerization as a novel mechanism for the regulation of Wnt/?-catenin signaling. J Cell Sci 127:4857-69
Fu, Suhua; Zhu, Meili; Ash, John D et al. (2014) Investigating the role of retinal Müller cells with approaches in genetics and cell biology. Adv Exp Med Biol 801:401-5
Crosswhite, Patrick; Chen, Kai; Sun, Zhongjie (2014) AAV delivery of tumor necrosis factor-? short hairpin RNA attenuates cold-induced pulmonary hypertension and pulmonary arterial remodeling. Hypertension 64:1141-50
Liu, Hongtao; Wang, Zhongxiao; Yu, Shujie et al. (2014) Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory response†. Cardiovasc Res 103:131-9

Showing the most recent 10 out of 20 publications