The goals of the Biostatistics Core are to promote and facilitate the research undertaken by the Junior Investigators in the COBRE, as well as to enhance research capabilities in the institution. The Biostatistics Core will provide support for the development of analytical capabilities at all levels of the COBRE, including technicians and mentors, but especially focusing upon the Junior Investigators. As a potential collaborator for all research projects, the Biostatistics Core will be an integral part of the research team in the development of research studies;as well as providing ongoing statistical and analytical advice throughout the life of each individual project. Services will be accordingly tailored to the individual Junior Investigator and could include advice or participation in database construction, web pages to advertise studies involving human subjects, experimental design, statistics, and publications.

National Institute of Health (NIH)
Exploratory Grants (P20)
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Special Emphasis Panel (ZRR1)
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Oklahoma City
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Hu, Shuqun; Liu, Hua; Ha, Yonju et al. (2015) Posttranslational modification of Sirt6 activity by peroxynitrite. Free Radic Biol Med 79:176-85
McBride, Jeffrey D; Jenkins, Alicia J; Liu, Xiaochen et al. (2014) Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol 134:1725-34
Zhou, Kelu Kevin; Benyajati, Siribhinya; Le, Yun et al. (2014) Interruption of Wnt signaling in Müller cells ameliorates ischemia-induced retinal neovascularization. PLoS One 9:e108454
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Fu, Shuhua; Zhu, Meili; Wang, Changyun et al. (2014) Efficient induction of productive Cre-mediated recombination in retinal pigment epithelium. Mol Vis 20:480-7
Takahashi, Yusuke; Moiseyev, Gennadiy; Ma, Jian-xing (2014) Identification of key residues determining isomerohydrolase activity of human RPE65. J Biol Chem 289:26743-51
Lee, Kyungwon; Shin, Younghwa; Cheng, Rui et al. (2014) Receptor heterodimerization as a novel mechanism for the regulation of Wnt/?-catenin signaling. J Cell Sci 127:4857-69
Fu, Suhua; Zhu, Meili; Ash, John D et al. (2014) Investigating the role of retinal Müller cells with approaches in genetics and cell biology. Adv Exp Med Biol 801:401-5
Crosswhite, Patrick; Chen, Kai; Sun, Zhongjie (2014) AAV delivery of tumor necrosis factor-? short hairpin RNA attenuates cold-induced pulmonary hypertension and pulmonary arterial remodeling. Hypertension 64:1141-50
Liu, Hongtao; Wang, Zhongxiao; Yu, Shujie et al. (2014) Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory response†. Cardiovasc Res 103:131-9

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