The long-term goal of the Center of Biomedical Research Excellence (COBRE) is to develop a multidisciplinary translational research center focusing on discovering cartilage and joint health and disease mechanisms and developing repair strategy. During the Phase I of COBRE, great progress has been made in mentoring junior investigators into leaders of R01 grant funded research programs. The main objective of the Phase II COBRE is to sustain the success by recruiting more promising junior investigators into the COBRE research programs thereby further expanding and enhancing the base of skeletal research in Rhode Island Hospital and Brown University. The new research projects encompass clinical, biological, and engineering research fields. Project 1 analyzes how mechanical loading affects long bone growth during skeletal development. Project 2 examine how joint cartilage degenerates in adult joint diseases. Project 3 develops novel strategies of harvesting stem cells from fat tissues to repair bone. The investigators and mentors are selected from three departments in Rhode Island Hospital/The Alpert Medical School of Brown University (Orthopaedics, Medicine, and Molecular Pharmacology, Physiology, and Biotechnology). The junior investigators include a biologist, a bioengineer, and a clinician/scientist. The mentors also include biologists, engineers, and clinician/scientists. Eachmentor is a Principal Investigator of multiple federal grants including NIH R01. They will supervise junior investigator's research projects, serve as their role models, and mentor them to obtain federal research project grants. Our vision is, by sustaining and developing this research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators with senior investigators, and biologists with bioengineers. This multidisciplinary approach is absolutely necessary to develop translational strategies for prevention and treatment of skeletal joint diseases.
Cartilage and joint diseases, a research focus of our COBRE, are a leading cause of disability nationally, affecting an estimated 46.4 million U.S. citizens -more than one in every five adults aged 18 or older. The alarming figures of cartilage and joint diseases are compounded by the enormous costs we bear for arthritis treatment, its complications and the resulting disability. The prevalence of the join disease rates illustrates the significance for research, treatment, and prevention of these debilitating diseases.
|Kiapour, Ata M; Shalvoy, Matthew R; Murray, Martha M et al. (2015) Validation of porcine knee as a sex-specific model to study human anterior cruciate ligament disorders. Clin Orthop Relat Res 473:639-50|
|Zhou, Jingming; Chen, Qian; Lanske, Beate et al. (2014) Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice. Arthritis Res Ther 16:R11|
|Kanthilal, Manisha; Darling, Eric M (2014) Characterization of mechanical and regenerative properties of human, adipose stromal cells. Cell Mol Bioeng 7:585-597|
|Guo, Liangran; Yan, Daisy D; Yang, Dongfang et al. (2014) Combinatorial photothermal and immuno cancer therapy using chitosan-coated hollow copper sulfide nanoparticles. ACS Nano 8:5670-81|
|Foradori, Matthew J; Chen, Qian; Fernandez, Cecilia A et al. (2014) Matrilin-1 is an inhibitor of neovascularization. J Biol Chem 289:14301-9|
|Desai, Hetal V; Voruganti, Indu S; Jayasuriya, Chathuraka et al. (2014) Live-cell, temporal gene expression analysis of osteogenic differentiation in adipose-derived stem cells. Tissue Eng Part A 20:899-907|
|Toyjanova, Jennet; Hannen, Erin; Bar-Kochba, Eyal et al. (2014) 3D Viscoelastic traction force microscopy. Soft Matter 10:8095-106|
|Zhou, Jingming; Wei, Xiaochun; Wei, Lei (2014) Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration disease. Connect Tissue Res 55:257-61|
|Fawzi, Nicolas L; Libich, David S; Ying, Jinfa et al. (2014) Characterizing methyl-bearing side chain contacts and dynamics mediating amyloid ? protofibril interactions using ¹³C(methyl)-DEST and lifetime line broadening. Angew Chem Int Ed Engl 53:10345-9|
|Gonzalez, David M; Medici, Damian (2014) Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal 7:re8|
Showing the most recent 10 out of 24 publications