Mastitis is a common infection ofthe breast during lactation. Mastitis is either infective or due to milk stasis and induces inflammation in the extracellular matrix or stroma of the breast. Mastitis resolves with treatment but causes involution of mammary lobules. Episodes of mastitis are known to increase the risk of breast cancer. Moreover, in the post-lactation period, the breast cancer risk is increased, independent of mastitis. This is in part due to the induction of inflammatory genes during the process of involution. This project aims to determine if breast cancer develops more readily in a post-mastitis milieu. Using high-throughput technologies, we aim to define the acute and chronic changes that mastitis induces in the extracellular matrix (stroma) and how these changes contribute to the formation of breast cancer. Lastly, we aim to define the effects of mastitis on PTHrP signaling in the mammary stroma and PTHrP's role in promoting breast cancer via its effects on mammary stem cells. As a Junior Investigator in the COBRE in Matrix Biology, I will work with my scientific mentor to complete the scientific aims and to develop a grant proposal for future R01 funding.
): Breast cancer progression is worsened by both inflammation and the stiffness of the extracellular matrix. Successful completion ofthe proposed aims will result in an improved understanding ofthe forces driving breast cancer progression, and the identification of potential therapeutic targets.
|MourÃ£o, AndrÃ©; Bonnal, Sophie; Soni, Komal et al. (2016) Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation. Elife 5:|
|Turner, Matthew W; Cruz, Roberto; Mattos, Jared et al. (2016) Cyclopamine bioactivity by extraction method from Veratrum californicum. Bioorg Med Chem 24:3752-7|
|Morrison, Brad E (2016) Discovery of nigral dopaminergic neurogenesis in adult mice. Neural Regen Res 11:878-81|
|Krueger, Eric; Shim, Jiwook; Fathizadeh, Arman et al. (2016) Modeling and Analysis of Intercalant Effects on Circular DNA Conformation. ACS Nano 10:8910-7|
|Bryant, Sheenah; Shrestha, Nisha; Carnig, Paul et al. (2016) Purinergic control of lysenin's transport and voltage-gating properties. Purinergic Signal 12:549-59|
|Krueger, Eric; Bryant, Sheenah; Shrestha, Nisha et al. (2016) Intramembrane congestion effects on lysenin channel voltage-induced gating. Eur Biophys J 45:187-94|
|Porter, Stephen M; Dailey, Hannah L; Hollar, Katherine A et al. (2016) Automated measurement of fracture callus in radiographs using portable software. J Orthop Res 34:1224-33|
|Albright, Joshua E; Stojkovska, Iva; Rahman, Abir A et al. (2016) Nestin-positive/SOX2-negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice. Neurosci Lett 615:50-4|
|Harvey, Wendy A; Jurgensen, Kimberly; Pu, Xinzhu et al. (2016) Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases human hepatic stellate cell activation. Toxicology 344-346:26-33|
|Elkins, Jacob; Marsh, J Lawrence; Lujan, Trevor et al. (2016) Motion Predicts Clinical Callus Formation: Construct-Specific Finite Element Analysis of Supracondylar Femoral Fractures. J Bone Joint Surg Am 98:276-84|
Showing the most recent 10 out of 27 publications