The overall objecfive of the Experimental Stroke Core (ESC) is to provide the instrumentation, expertise, resources and training for the incorporafion of animal models of stroke into the research of junior invesfigators in the Stroke CoBRE and researchers in the greater WVU neuroscience and cardiovascular research community. This overall objective would be reached by achieving the following specific aims:
Specific Aim 1 : To provide the instrumentafion, expertise and resources needed to produce strokes in rodent models. The ESC will be Director by James W. Simpkins (Core Director, CD) and he will be assessed by Dr. Xuefang Ren (Core Manager, CM), and James M. O'Donnell will oversee the behavioral assessment of animals.
Specific Aim 2 : To broadly notify the availability of these core services and resources to the greater WVU neuroscience and cardiovascular community. The availability ofthese services and resources are being and will confinue to be presented to the WVU neuroscience and cardiovascular research community through individual meefings, seminars, presentafions to neuroscience and cardiovascular group meetings and departmental seminars.
Specific Aim 3 : To provide processes by which users can access the core instrumentation, expertise and resources. Procedures for requesting use of core resources are described and include a brief applicafion describing the rationale for the proposed studies and the proposed design of the study to be conducted.
Specific Aim 4 : To provide training in experimental stroke research. Twice per year, the CD and CM will organize trainings session on the theory, practice and outcome interpretations for potenfial users of the core.
Specific Aim 5 : To develop and implement a business plan for the ESC that will insure its sustainability. A business plan for the ESC is in development by the CD and will be reviewed by the Core Resource Management Committee of the WVU Health Science Center.
Specific Aim 6 : To develop formafive and summative evaluafion processes for the ESC. Collectively, achieving these specific aims will insure a highly funcfioning ESC that will provide a vital sen/ice to the Stroke CoBRE junior invesfigators and to the greater WVU neuroscience and cardiovascular research community.
A highly funcfioning ESC that will provide a vital service to the Stroke CoBRE junior investigators and to the greater WVU neuroscience and cardiovascular research community and help posifion us for competifiveness for center and program project grant applications. Success of this ESC is a necessary component of our development of a national centerfor excellence in basic and translational stroke research.
|Sun, Jiahong; Ren, Xuefang; Qi, Wen et al. (2016) Geissoschizine methyl ether protects oxidative stress-mediated cytotoxicity in neurons through the 'Neuronal Warburg Effect'. J Ethnopharmacol 187:249-58|
|Engler-Chiurazzi, E B; Singh, M; Simpkins, J W (2016) From the 90's to now: A brief historical perspective on more than two decades of estrogen neuroprotection. Brain Res 1633:96-100|
|Engler-Chiurazzi, E B; Brown, C M; Povroznik, J M et al. (2016) Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury. Prog Neurobiol :|
|Engler-Chiurazzi, Elizabeth B; Covey, Douglas F; Simpkins, James W (2016) A novel mechanism of non-feminizing estrogens in neuroprotection. Exp Gerontol :|
|Petrone, Ashley B; O'Connell, Grant C; Regier, Michael D et al. (2016) The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity. Transl Stroke Res 7:103-10|
|Sarkar, S; Jun, S; Rellick, S et al. (2016) Expression of microRNA-34a in Alzheimer's disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity. Brain Res 1646:139-51|
|Hu, Heng; Doll, Danielle N; Sun, Jiahong et al. (2016) Mitochondrial Impairment in Cerebrovascular Endothelial Cells is Involved in the Correlation between Body Temperature and Stroke Severity. Aging Dis 7:14-27|
|Engler-Chiurazzi, Elizabeth B; Stapleton, Phoebe A; Stalnaker, Jessica J et al. (2016) Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition. J Toxicol Environ Health A 79:447-52|
|Sun, Jiahong; Hu, Heng; Ren, Xuefang et al. (2016) Tert-butylhydroquinone compromises survival in murine experimental stroke. Neurotoxicol Teratol 54:15-21|
|DeVallance, E; Fournier, S; Lemaster, K et al. (2016) The effects of resistance exercise training on arterial stiffness in metabolic syndrome. Eur J Appl Physiol 116:899-910|
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