Genomics is a key element of the overall systems biology program proposed for the Center for Translational Pediatric Research (CTPR) and is an essential component of the Research Projects proposed by the COBRE Project Leaders. The Genomics Core is an existing core facility that will be adapted and expanded to meet the research needs of the proposed COBRE Center. The next-generation sequencing capabilities, core personnel and laboratory facilities already in place are strong and will continue to operate largely as they currently do but will be enhanced with new approaches needed by CTPR members. The Genomics Core will coordinate closely with the CTPR Proteomics and Systems Biology Bioinformatics Cores to provide a one-of-a-kind systems biology approach for pediatric disease research. This coordinated core structure will allow genomics to be integrated in a cross-disciplinary framework capable of supporting the entire range of technologies and expertise needed for an effective systems biology approach for clinical and basic research. Close interaction between the Genomics Core and COBRE Center Project Leaders will also lead to new innovations in research methods that will benefit future COBRE investigators as well as the broader campus research community. Opportunities and training in the systems biology technologies will be provided to CTPR members, the campus and researchers in Arkansas.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
1P20GM121293-01
Application #
9210173
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Arkansas Children's Hospital Research Institute
Department
Type
DUNS #
002593692
City
Little Rock
State
AR
Country
United States
Zip Code
72202
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Holthoff, Emily R; Byrum, Stephanie D; Mackintosh, Samuel G et al. (2017) Vulvar squamous cell carcinoma aggressiveness is associated with differential expression of collagen and STAT1. Clin Proteomics 14:40