The Center for Cancer Research and Therapeutic Development (CCRTD) was established in 1999 at Clark Atlanta University to carry-out basic research in cancer biology and drug discovery. In 2004, the CCRTD decided to concentrate in the area of prostate cancer due to disproportionately higher incidence and mortality rate of this disease in African-American men. The current proposal requests support to continue the Center of Excellence in Prostate Cancer Research, Education and Community Education. The main objectives of this center will be 1) To carry out high quality basic research in cell and molecular biology of prostate cancer and to identify underlying biological reasons for racial disparities, 2) To continue our training program for undergraduate and graduate students to provide research training in the area of prostate cancer and hence increase the number of minority (primarily African American) scientists in this area of research, 3) To expand the community-based educational program for raising awareness on prevention, screening, early detection and treatment of prostate cancer. These goals will be achieved in collaboration with the Clark Atlanta University Division of Communication Arts, Midtown Urology Educational Foundation, Saint Joseph's Hospital Men's Health and Wellness Center, and other community organizations. In the Research Core, we propose three research projects focusing on prostate cancer cell and molecular biology and racial disparities. In the Training Core, we are requesting support for training of four graduate and six undergraduate students in the area of cancer biology and community service. In the Community Outreach/Education Core, we are requesting support to expand upon the community outreach and educational activities to include a larger media arena and coverage. The overall activities of the center will be monitored by the Administrative Core. The activities of the Administrative Core will be overseen by the Institutional (lAC), External (EAC) and Local External (LEAC) Advisory Committees. The long term goals of the center will be to understand the biology of prostate cancer, to increase the number of African-American scientists in cancer research, and to educate the African-American community in the areas of prostate cancer prevention, early detection and treatment.

Public Health Relevance

Prostate cancer affects the African-American community disproportionately. There is an increased incidence/mortality rate for African-American men, however the reason for this is unknown. The Center for Cancer Research and Therapeutic Development is committed to focus on the impact of this health disparity within the African-American community

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Exploratory Grants (P20)
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Special Emphasis Panel (ZMD1-RN (04))
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Mcclure, Shelia A
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Clark Atlanta University
Schools of Arts and Sciences
United States
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Sheng, Xiumei; Wang, Zhengxin (2016) Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation. BMC Cancer 16:567
Sheng, Xiumei; Bowen, Nathan; Wang, Zhengxin (2016) GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer. Mol Cancer 15:25
Bhosle, Sushma M; Hunt, Aisha; Chaudhary, Jaideep (2016) A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines. Biol Proced Online 18:9
Komaragiri, Shravan Kumar; Bostanthirige, Dhanushka H; Morton, Derrick J et al. (2016) ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells. Biochem Biophys Res Commun 478:60-6
Millena, Ana Cecilia; Vo, BaoHan T; Khan, Shafiq A (2016) JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-β (TGF-β)-induced Inhibition of Cell Proliferation. J Biol Chem 291:17964-76
Patel, Divya; Morton, Derrick J; Carey, Jason et al. (2015) Inhibitor of differentiation 4 (ID4): From development to cancer. Biochim Biophys Acta 1855:92-103
Chinaranagari, Swathi; Sharma, Pankaj; Bowen, Nathan J et al. (2015) Prostate cancer epigenome. Methods Mol Biol 1238:125-40
Henderson, Veronica; Smith, Basil; Burton, Liza J et al. (2015) Snail promotes cell migration through PI3K/AKT-dependent Rac1 activation as well as PI3K/AKT-independent pathways during prostate cancer progression. Cell Adh Migr 9:255-64
Brown, Shanora G; Knowell, Ashley E; Hunt, Aisha et al. (2015) Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis. Prostate 75:266-79
Burton, Liza J; Smith, Basil A; Smith, Bethany N et al. (2015) Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells. Carcinogenesis 36:1019-27

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