Florida A&M University (FAMU) College of Pharmacy and Pharmaceutical Sciences (COPPS) proposes the establishment of an Exploratory Center of Excellence (COE) in the area of Cancer Research, Training and Community Service (CRTCS). African-Americans experience the highest mortality rates associated with most cancer (breast, lung, prostate, etc.) deaths despite decreases in morbidity rates for all other racial and ethnic groups since early 1990. Health disparities are closely related to underlying socioeconomic inequalities and have been linked to racial differences among cancer mortality which presents major challenges across the entire spectrum of cancer prevention, early detection, and access to high quality care for disadvantage and underrepresented groups. The overall goal and objective of the COE CRTCS will consist of researchers focusing on developing innovative cancer research (breast and lung) abnormalities utilizing an interdisciplinary and synergistic approach toward addressing some of the most significant health consequences in minority and socioeconomic disadvantaged populations. This will address novel and innovative approaches to treating and preventing breast and lung cancer. The administrative;biomedical and behavioral research;research training/educational and community engagement/outreach cores will enable the COE CRTCS to accomplish the proposed initiatives.
The specific aims of the COE CRTCS are to: 1) Develop detailed innovative research plans that will address specific cancer (breast and lung) health issues that disproportionately impact African-American;2) Develop a research team conducting cancer research;3) Train minority PhD graduate students in health disparities research affecting disadvantage and minority populations;4) Increase the number of minority scientists engaged in biomedical and behavioral research;5) Establish and enhance community outreach and information dissemination activities that will increase prevention efforts and foster early detection towards reducing breast cancer in African-American women (Leon and Gadsden County, Florida);6) Establish and expand partnerships with community engagement/outreach organizations toward addressing and conducting minority health and other health disparities issues;and 7) Position FAMU to become more competitive in securing mainstream funding in biomedical and behavioral research support and addressing minority health disparities. The support of this application will promote minority health and aid i the elimination of health disparities as it relates to breast (among African-American females) and lung cancer (among minorities).

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD006738-03
Application #
8611733
Study Section
Special Emphasis Panel (ZMD1-RN (01))
Program Officer
Tabor, Derrick C
Project Start
2012-06-16
Project End
2017-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
3
Fiscal Year
2014
Total Cost
$1,015,159
Indirect Cost
$267,962
Name
Florida Agricultural and Mechanical University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
623751831
City
Tallahassee
State
FL
Country
United States
Zip Code
32307
Odewumi, Caroline O; Fils-Aime, Shiela; Badisa, Veera L D et al. (2015) Chemoprotective effect of monoisoamyl 2, 3-dimercaptosuccinate (MiADMS) on cytokines expression in cadmium chloride treated human lung cells. Environ Toxicol 30:704-11
Bauer, David; Mazzio, Elizabeth; Soliman, Karam Fa et al. (2014) Diallyl disulfide inhibits TNF?-induced CCL2 release by MDA-MB-231 cells. Anticancer Res 34:2763-70
Green, Jennifer E; Cooperwood, John S; Taka, Equar et al. (2014) Comparative proteomic analysis reveals growth inhibition by 3-N-alkyloxyestradiol derivative (SERM) in prostate cancer cells. Cancer Genomics Proteomics 11:195-200
Patel, Apurva R; Lim, Ed; Francis, Kevin P et al. (2014) Opening up the optical imaging window using nano-luciferin. Pharm Res 31:3073-84
Mazzio, E; Badisa, R; Mack, N et al. (2014) High throughput screening of natural products for anti-mitotic effects in MDA-MB-231 human breast carcinoma cells. Phytother Res 28:856-67
Badisa, Ramesh B; Mina, David A; Latinwo, Lekan M et al. (2014) Selective anticancer activity of neurotoxin 1-methyl-4-phenylpyridinium on non-small cell lung adenocarcinoma A549 cells. Anticancer Res 34:5447-52
Agyare, Edward K; Jaruszewski, Kristen M; Curran, Geoffry L et al. (2014) Engineering theranostic nanovehicles capable of targeting cerebrovascular amyloid deposits. J Control Release 185:121-9
Gangapuram, Madhavi; Mazzio, Elizabeth; Eyunni, Suresh et al. (2014) Synthesis and biological evaluation of substituted N-[3-(1H-pyrrol-1-yl)methyl]-1,2,5,6-tetrahydropyridin-1-yl]benzamide/benzene sulfonamides as anti-inflammatory agents. Arch Pharm (Weinheim) 347:360-9
Mazzio, Elizabeth A; Soliman, Karam F A (2014) Epigenetics and nutritional environmental signals. Integr Comp Biol 54:21-30
Chougule, Mahavir B; Patel, Apurva R; Patlolla, Ram et al. (2014) Epithelial transport of noscapine across cell monolayer and influence of absorption enhancers on in vitro permeation and bioavailability: implications for intestinal absorption. J Drug Target 22:498-508

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