It is postulated that one of the most effective strategies to ameliorate health disparities is to reduce tobacco exposure among African-American (AA) children and their parents. Exposure to the deleterious effects of involuntary secondhand smoking remains a major public health hazard;particularly for the most vulnerable in our society ~ children. Population-based surveys indicate that approximately 50% of children manifest exposure to secondhand smoke (SHS);and that AA children exhibit the highest rates of SHS exposure. The high rate of SHS exposure in children is particularly alarming because the life-course of smoking-related diseases such as asthma, hypertension, diabetes and cardiovascular disease have their onset during childhood. We anticipate that children living in the predominately low-income, AA partner community targeted by this MSM CEHD Program are particularly vulnerable to this toxin exposure. However, the causes and pathobiological consequences of SHS exposure in AA children remain poorly defined. This project will provide the first in-depth characterization of the social determinants and effects of SHS exposure on cardiovascular, metabolic and pulmonary health in AA children. These studies will provide new insights that will guide the development of more effective interventions to prevent tobacco exposure in AA families. Our approach utilizes a socio-ecological model of childhood SHS exposure that posits a multi-level interplay between the child's neighborhood characteristics, family context and individual biological factors. Our working hypothesis poses that certain elements in the 'built environment'predispose AA children to increased involuntary tobacco exposure (e.g. high density of tobacco marketing outlets;crowded housing conditions). Secondly, we hypothesize that parents determine childhood SHS exposure by: 1) parent risk behaviors (e.g. parent tobacco smoking), 2) parent health literacy and 3) parent psychosocial factors that influence childhood SHS exposure (perceived stress;social support). The project's specific aims are:
Aim 1 : Define the neighborhood characteristics, psychosocial factors and parenting behaviors associated with high secondhand smoke exposure in African-American children.
Aim 2 : Define the relationship between secondhand smoke exposure during childhood and vascular dysfunction, a pre-clinical marker of cardio-metabolic disease.
Aim 3 : Develop a predictive model to identify vulnerable children at high-risk for SHS exposure.
One of the most effective strategies to ameliorate health disparities is to reduce tobacco exposure among African-American (AA) children and their parents. Approximately 50% of children manifest exposure to second hand smoke (SHS);and AA children exhibit the highest rates of SHS exposure. This project will provide the first in-depth characterization of the social determinants and effects of SHS exposure on cardiovascular, metabolic and pulmonary health in AA children.
|Ansa, Benjamin E; White, Sashia; Chung, Yunmi et al. (2016) Trends in HIV Testing among Adults in Georgia: Analysis of the 2011-2015 BRFSS Data. Int J Environ Res Public Health 13:|
|Adedinsewo, Demilade; Taka, Nchang; Agasthi, Pradyumna et al. (2016) Prevalence and Factors Associated With Statin Use Among a Nationally Representative Sample of US Adults: National Health and Nutrition Examination Survey, 2011-2012. Clin Cardiol 39:491-6|
|Bolar, Cassandra L; Hernandez, Natalie; Akintobi, Tabia Henry et al. (2016) Context matters: A community-based study of urban minority parents' views on child health. J Ga Public Health Assoc 5:212-219|
|Rust, George; Zhang, Shun; Malhotra, Khusdeep et al. (2015) Paths to health equity: Local area variation in progress toward eliminating breast cancer mortality disparities, 1990-2009. Cancer 121:2765-74|
|Zhang, Shun; Rust, George; Cardarelli, Kathryn et al. (2015) Adherence to highly active antiretroviral therapy impact on clinical and economic outcomes for Medicaid enrollees with human immunodeficiency virus and hepatitis C coinfection. AIDS Care 27:829-35|
|Smith, Selina A; Claridy, Mechelle D; Whitehead, Mary Smith et al. (2015) Lifestyle Modification Experiences of African American Breast Cancer Survivors: A Needs Assessment. JMIR Cancer 1:|
|Holden, Kisha; Charles, Lisa; King, Stephen et al. (2015) Reducing Health Disparities and Improving Health Equity in Saint Lucia. Int J Environ Res Public Health 13:ijerph13010037|
|Ansa, Benjamin; Yoo, Wonsuk; Whitehead, Mary et al. (2015) Beliefs and Behaviors about Breast Cancer Recurrence Risk Reduction among African American Breast Cancer Survivors. Int J Environ Res Public Health 13:ijerph13010046|
|Xu, Jingyao; Agyemang, Stephanie; Qin, Yunlong et al. (2014) A Novel Pathway that Links Caveolin-1 Down-Regulation to BRCA1 Dysfunction in Serous Epithelial Ovarian Cancer Cells. Enliven Chall Cancer Detect Ther 1:|
|Malhotra, Khusdeep; Baltrus, Peter; Zhang, Shun et al. (2014) Geographic and racial variation in asthma prevalence and emergency department use among Medicaid-enrolled children in 14 southern states. J Asthma 51:913-21|
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