The purpose of our integrated research core and project components is to reduce health disparities, which disproportionately affect women, minorities, and low-income individuals. Our projects and research core components are guided by research principles derived from community-based participatory research (CBPR) and translational research. In the present proposal we will focus on problems related directly to women's health disparities, by presenting three projects of significant importance for women in the United States, HIV/AIDS, Breast Cancer, and Obesity: Project 1: Dr. Anuja Ghorpade, PI.'Health Disparities &sCD40L: Novel Biomarkers for HIV-1 Disease Progression. This project will study the levels of soluble CD40L as a prognostic biomarker for HIV/AIDS disease progression in the context of race and gender. Project 2: Dr. JK Vishwanatha, PI. Triple Negative Breast Cancer: Novel Biomarkers and Therapeutic Strategies. In this project the expression characteristics of Annexin A2 will be linked to the evolution of triplenegative breast cancer in African-American women. Project 3: Dr. Mark J. DeHaven, PI. Reducing Obesity in African American Women through Lifestyle Enhancement. This project will evaluate a means for reducing weight among African-American women through a CBPR partnership with African-American congregations. The integrated specific aims are to: 1) Develop an integrated platform and structure for addressing significant health problems related to Women's Health Disparities;2) Perform high-quality research in Women's Health Disparities in the areas of HIV/AIDS, Breast Cancer, and Obesity in a way that will reduce prevalent health disparities;3) Provide research opportunities for under-represented minority students (URM) and faculty to participate in meaningful research designed to eliminate Women's Health Disparities, through collaboration between the Research Core and the Education/Training Core;4) Enhance communitybased participation in Women's Health Disparities research through collaboration between the Research Core and the Community Outreach Core;and, 5) Characterize biomarkers and/or risk factors for future therapeutic avenues with a specific emphasis on Women's Health Disparities.

Public Health Relevance

Healthy People 2020 is designed to achieve health equity, eliminate disparities, and improve the health of all Americans. Significant health disparities characterize HIV/AID, Breast Cancer, and Obesity. By employing community-based participatory research (CBPR) and translational - bench to bedside to curbside - research approaches and projects, our research promotes health equity and eliminating health disparities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
1P20MD006882-01
Application #
8351380
Study Section
Special Emphasis Panel (ZMD1-RN (01))
Project Start
Project End
Budget Start
2012-07-16
Budget End
2013-05-31
Support Year
1
Fiscal Year
2012
Total Cost
$172,396
Indirect Cost
$52,271
Name
University of North Texas
Department
Type
DUNS #
110091808
City
Fort Worth
State
TX
Country
United States
Zip Code
76107
Vishwanatha, Jamboor K; Jones, Harlan P (2018) Implementation of The Steps Toward Academic Research (STAR) Fellowship Program to Promote Underrepresented Minority Faculty into Health Disparity Research. Ethn Dis 28:3-10
Gibbs, Lee D; Chaudhary, Pankaj; Mansheim, Kelsey et al. (2018) ANXA2 expression in African American triple-negative breast cancer patients. Breast Cancer Res Treat :
Gibbs, Lee D; Vishwanatha, Jamboor K (2018) Prognostic impact of AnxA1 and AnxA2 gene expression in triple-negative breast cancer. Oncotarget 9:2697-2704
Gdowski, Andrew; Johnson, Kaitlyn; Shah, Sunil et al. (2018) Optimization and scale up of microfluidic nanolipomer production method for preclinical and potential clinical trials. J Nanobiotechnology 16:12
Bullock, Katura C (2017) Development, implementation, and evaluation of a service-learning series for pharmacy students using a public health tool. Curr Pharm Teach Learn 9:828-834
Gdowski, Andrew S; Ranjan, Amalendu; Sarker, Marjana R et al. (2017) Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. Nanomedicine (Lond) 12:2083-2095
Maji, Sayantan; Chaudhary, Pankaj; Akopova, Irina et al. (2017) Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis. Mol Cancer Res 15:93-105
Tan, Marissa; Mamun, Abdullah; Kitzman, Heather et al. (2017) Neighborhood Disadvantage and Allostatic Load in African American Women at Risk for Obesity-Related Diseases. Prev Chronic Dis 14:E119
Kitzman, Heather; Dodgen, Leilani; Mamun, Abdullah et al. (2017) Community-based participatory research to design a faith-enhanced diabetes prevention program: The Better Me Within randomized trial. Contemp Clin Trials 62:77-90
Rajendiran, Smrithi; Gibbs, Lee D; Van Treuren, Timothy et al. (2016) MIEN1 is tightly regulated by SINE Alu methylation in its promoter. Oncotarget 7:65307-65319

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