The proposed Research Training/Education Core consists of programs and activities directed at increasing the number of students from underrepresented minority groups, who participate in biomedical and public health educational programs and applied research training experiences related to health disparities. Consistent with the proposed focus ofthe Research Core, the research training programs will focus specifically in the area of Women's Health Disparities. Working through the existing Texas Center for Health Disparities (TCHD) infrastructure, the specific aims ofthe Research Training/Education Core are: 1) to support the professional development of faculty and community stakeholders in health disparities research and (2) to enhance health disparities research opportunities for URM undergraduate students. The TCHD sponsors a successful fellowship program, the Steps Toward Academic Research (STAR) Fellowship. The STAR Fellowship was developed as a component of our institution's EXPORT Center activities from 2005 - 2010, and has become a centerpiece ofthe UNTHSC Coordinated Plan for minority education and research. It provides unique opportunities for underrepresented minority (URM) students from K-12 throughout postdoctorate training to learn about and engage in health disparities education and research. A primary element of our proposed COE, will be to renew, update, and expand the STAR Fellowship. The program will be expanded by more extensively incorporating Community-based Participatory Research (CBPR) training and activities into the program curriculum, and by also developing a Community Fellows Track into the STAR Fellowship program. The Research Training/Education program will be led by Drs. Jose A. Pagan, Hadan P. Jones, and Robert Kaman. This leadership team bnngs together transdisciplinary expertise in research and research training related to CBPR (Pagan and Kaman), health disparities in social and behavioral sciences (Pagan and Kaman), biomedical sciences (Jones), public health law (Kaman), health care management and health economics (Pagan), and health policy (Pagan and Kaman). Consistent with the specific goals ofthe Research Training/Education Core, extensive interactions with the research and outreach cores are integrated into all activities ofthe core.

Public Health Relevance

The Research Training/Education Core supports the professional development of students, faculty and community stakeholders in health disparities research. Supporting research training and educational activities at every level is relevant and important in order to meet the objective of developing a strong, minority-based cadre of research faculty at the UNTHSC and underrepresented minority serving institutions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD006882-02
Application #
8511823
Study Section
Special Emphasis Panel (ZMD1-RN)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
2
Fiscal Year
2013
Total Cost
$150,717
Indirect Cost
$46,700
Name
University of North Texas
Department
Type
DUNS #
110091808
City
Fort Worth
State
TX
Country
United States
Zip Code
76107
Basha, Riyaz; Connelly, Sarah F; Sankpal, Umesh T et al. (2016) Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution. J Nutr Biochem 31:77-87
Maji, Sayantan; Chaudhary, Pankaj; Akopova, Irina et al. (2016) Exosomal Annexin A2 Promotes Angiogenesis and Breast Cancer Metastasis. Mol Cancer Res :
Kokate, Rutika A; Chaudhary, Pankaj; Sun, Xiangle et al. (2016) Rationalizing the use of functionalized poly-lactic-co-glycolic acid nanoparticles for dendritic cell-based targeted anticancer therapy. Nanomedicine (Lond) 11:479-94
Kpetemey, Marilyne; Dasgupta, Subhamoy; Rajendiran, Smrithi et al. (2015) MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression. Mol Cancer 14:156
Rajendiran, Smrithi; Kpetemey, Marilyne; Maji, Sayantan et al. (2015) MIEN1 promotes oral cancer progression and implicates poor overall survival. Cancer Biol Ther 16:876-85
Kokate, Rutika A; Thamake, Sanjay I; Chaudhary, Pankaj et al. (2015) Enhancement of anti-tumor effect of particulate vaccine delivery system by 'bacteriomimetic' CpG functionalization of poly-lactic-co-glycolic acid nanoparticles. Nanomedicine (Lond) 10:915-29
Griner, Nicholas B; Young, Denise; Chaudhary, Pankaj et al. (2015) ERG oncoprotein inhibits ANXA2 expression and function in prostate cancer. Mol Cancer Res 13:368-79
Chaudhary, P; Thamake, S I; Shetty, P et al. (2014) Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. Br J Cancer 111:2328-41
Valapala, Mallika; Maji, Sayantan; Borejdo, Julian et al. (2014) Cell surface translocation of annexin A2 facilitates glutamate-induced extracellular proteolysis. J Biol Chem 289:15915-26
Rajendiran, Smrithi; Parwani, Anil V; Hare, Richard J et al. (2014) MicroRNA-940 suppresses prostate cancer migration and invasion by regulating MIEN1. Mol Cancer 13:250

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