The purpose of our integrated research core and project components is to reduce health disparities, which disproportionately affect women, minorities, and low-income individuals. Our projects and research core components are guided by research principles derived from community-based participatory research (CBPR) and translational research. In the present proposal we will focus on problems related directly to women's health disparities, by presenting three projects of significant importance for women in the United States, HIV/AIDS, Breast Cancer, and Obesity: Project 1: Dr. Anuja Ghorpade, PI.'Health Disparities &sCD40L: Novel Biomarkers for HIV-1 Disease Progression. This project will study the levels of soluble CD40L as a prognostic biomarker for HIV/AIDS disease progression in the context of race and gender. Project 2: Dr. JK Vishwanatha, PI. Triple Negative Breast Cancer: Novel Biomarkers and Therapeutic Strategies. In this project the expression characteristics of Annexin A2 will be linked to the evolution of triplenegative breast cancer in African-American women. Project 3: Dr. Mark J. DeHaven, PI. Reducing Obesity in African American Women through Lifestyle Enhancement. This project will evaluate a means for reducing weight among African-American women through a CBPR partnership with African-American congregations. The integrated specific aims are to: 1) Develop an integrated platform and structure for addressing significant health problems related to Women's Health Disparities;2) Perform high-quality research in Women's Health Disparities in the areas of HIV/AIDS, Breast Cancer, and Obesity in a way that will reduce prevalent health disparities;3) Provide research opportunities for under-represented minority students (URM) and faculty to participate in meaningful research designed to eliminate Women's Health Disparities, through collaboration between the Research Core and the Education/Training Core;4) Enhance communitybased participation in Women's Health Disparities research through collaboration between the Research Core and the Community Outreach Core;and, 5) Characterize biomarkers and/or risk factors for future therapeutic avenues with a specific emphasis on Women's Health Disparities.
Healthy People 2020 is designed to achieve health equity, eliminate disparities, and improve the health of all Americans. Significant health disparities characterize HIV/AID, Breast Cancer, and Obesity. By employing community-based participatory research (CBPR) and translational - bench to bedside to curbside - research approaches and projects, our research promotes health equity and eliminating health disparities.
|Basha, Riyaz; Connelly, Sarah F; Sankpal, Umesh T et al. (2016) Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution. J Nutr Biochem 31:77-87|
|Maji, Sayantan; Chaudhary, Pankaj; Akopova, Irina et al. (2016) Exosomal Annexin A2 Promotes Angiogenesis and Breast Cancer Metastasis. Mol Cancer Res :|
|Kokate, Rutika A; Chaudhary, Pankaj; Sun, Xiangle et al. (2016) Rationalizing the use of functionalized poly-lactic-co-glycolic acid nanoparticles for dendritic cell-based targeted anticancer therapy. Nanomedicine (Lond) 11:479-94|
|Kpetemey, Marilyne; Dasgupta, Subhamoy; Rajendiran, Smrithi et al. (2015) MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression. Mol Cancer 14:156|
|Rajendiran, Smrithi; Kpetemey, Marilyne; Maji, Sayantan et al. (2015) MIEN1 promotes oral cancer progression and implicates poor overall survival. Cancer Biol Ther 16:876-85|
|Kokate, Rutika A; Thamake, Sanjay I; Chaudhary, Pankaj et al. (2015) Enhancement of anti-tumor effect of particulate vaccine delivery system by 'bacteriomimetic' CpG functionalization of poly-lactic-co-glycolic acid nanoparticles. Nanomedicine (Lond) 10:915-29|
|Griner, Nicholas B; Young, Denise; Chaudhary, Pankaj et al. (2015) ERG oncoprotein inhibits ANXA2 expression and function in prostate cancer. Mol Cancer Res 13:368-79|
|Chaudhary, P; Thamake, S I; Shetty, P et al. (2014) Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. Br J Cancer 111:2328-41|
|Valapala, Mallika; Maji, Sayantan; Borejdo, Julian et al. (2014) Cell surface translocation of annexin A2 facilitates glutamate-induced extracellular proteolysis. J Biol Chem 289:15915-26|
|Rajendiran, Smrithi; Parwani, Anil V; Hare, Richard J et al. (2014) MicroRNA-940 suppresses prostate cancer migration and invasion by regulating MIEN1. Mol Cancer 13:250|
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