Eliminafing health disparifies is a major unmet need in our society. The concern is not only for equity and social jusfice. It will be impossible to fulfill our nafional goal to have a healthy populafion without addressing this need. Achieving this goal can be significanfiy enhanced by establishing health disparifies research centers across the nation that are ready to implement an agenda of research, education, training and community outreach activifies to support the goal of the NIMHD to eliminate disparifies. Implementing these activities requires an effective administrative structure that provides support and facilitates the execution of successful initiatives and research plans. Based on our experience in the previous grant cycle, it would not be possible to operate the Center with all of its acfivifies and maintain institutional support without a visible and efficient administrative core. The Administrative Core structure and function proposed in this application will be critical to achieve the major goals of our Center and the specific aims proposed by its other cores. For instance, we put significant attenfion into having an Administrative Core that addresses the needs of a young growing center. This plan provides adequate oversight through effective and experienced internal and external scientific leadership and avoids unnecessary bureaucracy and also fits well within the structure of the Center. The structure proposed for the Center was crafted in such a way that it addresses all LLU policies with respect to university centers, institutes and departments, and includes required oversight by LLU administrafion through an Internal Advisory panel. This was important to qualify for financial support in proportion to extramural funding generated similarly by other centers and departments. The External Advisory Panel includes a cadre of experienced nafional leaders in health disparifies that advise the Center Director and leadership team.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
1P20MD006988-01
Application #
8350952
Study Section
Special Emphasis Panel (ZMD1-RN (01))
Project Start
2012-07-01
Project End
Budget Start
2012-07-01
Budget End
2013-01-31
Support Year
1
Fiscal Year
2012
Total Cost
$192,115
Indirect Cost
$70,127
Name
Loma Linda University
Department
Type
DUNS #
009656273
City
Loma Linda
State
CA
Country
United States
Zip Code
92350
Francis, Olivia L; Milford, Terry-Ann M; Martinez, Shannalee R et al. (2016) A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis. Haematologica 101:417-26
Basu, Anamika; Cajigas-Du Ross, Christina K; Rios-Colon, Leslimar et al. (2016) LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer. PLoS One 11:e0146549
Spencer-Hwang, Rhonda; Soret, Sam; Ghamsary, Mark et al. (2016) Gender Differences in Respiratory Health of School Children Exposed to Rail Yard-Generated Air Pollution: The ENRRICH Study. J Environ Health 78:8-16
Milford, Terry-Ann M; Su, Ruijun J; Francis, Olivia L et al. (2016) TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis. Eur J Immunol 46:2155-61
Brantley, Eileen; Callero, Mariana A; Berardi, Damian E et al. (2016) AhR ligand Aminoflavone inhibits α6-integrin expression and breast cancer sphere-initiating capacity. Cancer Lett 376:53-61
Wang, Haijun; Song, Chunhua; Ding, Yali et al. (2016) Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia. J Biol Chem 291:4004-18
Díaz Osterman, Carlos J; Gonda, Amber; Stiff, TessaRae et al. (2016) Curcumin Induces Pancreatic Adenocarcinoma Cell Death Via Reduction of the Inhibitors of Apoptosis. Pancreas 45:101-9
Sanchez, Tino W; Zhang, Guangyu; Li, Jitian et al. (2016) Immunoseroproteomic Profiling in African American Men with Prostate Cancer: Evidence for an Autoantibody Response to Glycolysis and Plasminogen-Associated Proteins. Mol Cell Proteomics 15:3564-3580
Turay, David; Khan, Salma; Diaz Osterman, Carlos J et al. (2016) Proteomic Profiling of Serum-Derived Exosomes from Ethnically Diverse Prostate Cancer Patients. Cancer Invest 34:1-11
Salto, Lorena M; Bu, Liming; Beeson, W Lawrence et al. (2016) The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes. Int J Environ Res Public Health 13:ijerph13010052

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