The Loma Linda University Center for Health Disparities Research (LLU CHDR) was established by an EXPORT award from the NCMHD to develop new infrastructure for research in health disparities at LLU and the Inland Empire (IE) region of Southern California. The overall goal of this competitive renewal application is to support a successful enterprise that is already addressing health disparities in the IE. The four objectives of this application are: Objective 1: To enhance the research and administrative infrastructure of LLU to conduct competitive and sustainable research, training, education and outreach in health disparities. This objective will ensure having an efficient administrative infrastructure to support the center. Objective 2 is to build a successful enterprise in health disparities research leading to translational discoveries to reduce the burden of breast cancer, prostate cancer, and type 2 diabetes disparities. Innovative approaches to study gene-environmental interactions in type 2 diabetes in Mexican Americans, immunoseroproteomics profiling in African American men with prostate cancer, and triple negative breast cancer chemoreslstance in African American women, will lead the center to address these killer diseases that are disproportionately impacting underserved communities. Objective 3 is to sustain a comprehensive and robust pipeline of health disparities researchers from underrepresented and medically underserved populations. The center has identified a pool of hundreds of students from health disparities populations that have been participating in this successful program. Objective 4 is to engage with an established network of CBOs and LLU partnerships in addressing the problems of health disparities and to facilitate the translation of advances in breast cancer, prostate cancer and Type 2 diabetes to underserved communities. Fulfilling this objective will result in an army of trained and LLU certified """"""""Promotores"""""""" engaged in prevention education program to reduce the burden of health disparities diseases in this underserved region of California. Accomplishment of these objectives will make the LLU CHDR/CHDMM an established resource for excellence in research, training and successful partnership. .

Public Health Relevance

; This project has much public health relevance in that it will utilize multi-transdisciplinary research approaches and strategies to implement multi-level individual, population-based, and policy interventions to address health disparities, especially, as related to obesity, becoming a model in understanding and improving the health of minorities and underserved populations in Mississippi.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD006988-03
Application #
8609513
Study Section
Special Emphasis Panel (ZMD1-RN (01))
Program Officer
Tabor, Derrick C
Project Start
2012-07-01
Project End
2017-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
3
Fiscal Year
2014
Total Cost
$1,128,576
Indirect Cost
$396,573
Name
Loma Linda University
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
009656273
City
Loma Linda
State
CA
Country
United States
Zip Code
92350
Francis, Olivia L; Milford, Terry-Ann M; Martinez, Shannalee R et al. (2016) A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis. Haematologica 101:417-26
Basu, Anamika; Cajigas-Du Ross, Christina K; Rios-Colon, Leslimar et al. (2016) LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer. PLoS One 11:e0146549
Spencer-Hwang, Rhonda; Soret, Sam; Ghamsary, Mark et al. (2016) Gender Differences in Respiratory Health of School Children Exposed to Rail Yard-Generated Air Pollution: The ENRRICH Study. J Environ Health 78:8-16
Milford, Terry-Ann M; Su, Ruijun J; Francis, Olivia L et al. (2016) TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis. Eur J Immunol 46:2155-61
Brantley, Eileen; Callero, Mariana A; Berardi, Damian E et al. (2016) AhR ligand Aminoflavone inhibits α6-integrin expression and breast cancer sphere-initiating capacity. Cancer Lett 376:53-61
Wang, Haijun; Song, Chunhua; Ding, Yali et al. (2016) Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia. J Biol Chem 291:4004-18
Díaz Osterman, Carlos J; Gonda, Amber; Stiff, TessaRae et al. (2016) Curcumin Induces Pancreatic Adenocarcinoma Cell Death Via Reduction of the Inhibitors of Apoptosis. Pancreas 45:101-9
Sanchez, Tino W; Zhang, Guangyu; Li, Jitian et al. (2016) Immunoseroproteomic Profiling in African American Men with Prostate Cancer: Evidence for an Autoantibody Response to Glycolysis and Plasminogen-Associated Proteins. Mol Cell Proteomics 15:3564-3580
Turay, David; Khan, Salma; Diaz Osterman, Carlos J et al. (2016) Proteomic Profiling of Serum-Derived Exosomes from Ethnically Diverse Prostate Cancer Patients. Cancer Invest 34:1-11
Salto, Lorena M; Bu, Liming; Beeson, W Lawrence et al. (2016) The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes. Int J Environ Res Public Health 13:ijerph13010052

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