Depression is common and disabling. Advances in telecommunications have greatly increased the possibilities for delivering behavioral interventions. Unfortunately, the initial results in this emerging field indicate that much work remains before viable systems can be implemented clinically. The mission of this Center is to develop and pilot novel systems of care that can provide efficacious, scalable, cost-effective, patient friendly technology assisted behavioral interventions (TABIs) for the treatment and prevention of depression. The Center's model proposes that adherence and efficacy can be enhanced by increasing support from humans, creating greater connectedness to patients in their environments, and developing new interfaces that are more conducive to promoting complex behavior change. To this end, we will propose a Technology Development Unit that will develop and refine three new technologies that address each of these areas, two pilot trials that will test novel interventions in the treatment and prevention of depression, and two measurement projects that will develop and evaluate metrics. The Technology Development Unit will 1) refine mobile phone technology that can continuously monitor patient behavior, environmental context, and mood, and can reach out to engage the patient at critical moments in his/her environment, 2) refine an online peer network that is specifically designed to activate participants to provide support and encourage accountability among its members, and 3) develop programmable virtual humans to support interpersonal skills training. Two pilot trials will 1) evaluate these technologies in the context of an internet treatment for depression in adults and 2) evaluate these technologies in the context of an internet treatment for prevention of depression in adolescents. Measurement projects will, using data collected in the pilot trials, evaluate measurement in two critical areas for TABIs: adherence and cost-effectiveness.

Public Health Relevance

Depression is a common and disabling disorder affecting 10% of Americans each year. Most people with depression experience barriers to receiving treatment and receive sub-optimal treatment if they do access treatment. This center will develop and test novel methods of using telecommunications technologies to extend treatment and prevention into the patient's environment, with the aim of making interventions more effective and more available. This center has the potential to open an entirely new set of treatment options for patients with depression.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Exploratory Grants (P20)
Project #
5P20MH090318-03
Application #
8511829
Study Section
Special Emphasis Panel (ZMH1-ERB-B (01))
Program Officer
Chambers, David A
Project Start
2011-08-04
Project End
2016-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
3
Fiscal Year
2013
Total Cost
$914,357
Indirect Cost
$226,398
Name
Northwestern University at Chicago
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Schueller, Stephen M; Begale, Mark; Penedo, Frank J et al. (2014) Purple: a modular system for developing and deploying behavioral intervention technologies. J Med Internet Res 16:e181
Kalapatapu, Raj K; Ho, Joyce; Cai, Xuan et al. (2014) Cognitive-behavioral therapy in depressed primary care patients with co-occurring problematic alcohol use: effect of telephone-administered vs. face-to-face treatment-a secondary analysis. J Psychoactive Drugs 46:85-92
Mohr, David C; Schueller, Stephen M; Montague, Enid et al. (2014) The behavioral intervention technology model: an integrated conceptual and technological framework for eHealth and mHealth interventions. J Med Internet Res 16:e146
Mohr, David C; Cheung, Ken; Schueller, Stephen M et al. (2013) Continuous evaluation of evolving behavioral intervention technologies. Am J Prev Med 45:517-23
Mohr, David C; Burns, Michelle Nicole; Schueller, Stephen M et al. (2013) Behavioral intervention technologies: evidence review and recommendations for future research in mental health. Gen Hosp Psychiatry 35:332-8
Duffecy, Jennifer; Sanford, Stacy; Wagner, Lynne et al. (2013) Project onward: an innovative e-health intervention for cancer survivors. Psychooncology 22:947-51
Brown, C Hendricks; Mohr, David C; Gallo, Carlos G et al. (2013) A computational future for preventing HIV in minority communities: how advanced technology can improve implementation of effective programs. J Acquir Immune Defic Syndr 63 Suppl 1:S72-84