The goal of the currently funded Developmental Center on Injury Mechanisms and Related Responses (CIMRR) is to increase understanding of injury mechanisms and related responses by incorporating biologic techniques and measures into nursing studies and interdisciplinary investigations. The purpose of this competing continuation application is to continue to expand and strengthen the CIMRR by establishing a formal mechanism to support work on injury mechanisms and related responses involving genetics and gene function. New sub-objectives that will extend the original CIMRR aim (listed in the Overview Abstract) are: Sub-Objective 1. To establish a multi-user genomics facility to support research and sample preparation for studies related to: a) genomics (analysis of DNA), b) functional genomics (analysis of mRNA), and c) proteomics (analysis of proteins). (extends ClMRR Aim 1) Sub-Objective 2. To provide activities that: a) educate researchers on genomics-related subjects and techniques, and b) promote interdisciplinary discussion and collaboration on genomics. (extends ClMRR Aim 2) Sub-Objective 3. To continue to offer financial mechanisms of support for feasibility studies on injury mechanisms and related responses with special attention given to proposed work that involves genomics, functional genomics and proteomics. (extends CIMRR Aim 3) The Feasibility Study Core will share responsibility for Sub-Objective 2 with the Feasibility Studies Core. To accomplish sub-objective 2, the Feasibility Study Core will expand the methods and measures database and create web-based methods and measures demonstrations. The methods and measures database will be updated as new members join the CIMRR and annually for existing members. The web-based demonstrations will include content relevant to genomics and to injury mechanisms and related responses, in general. The Feasibility Study Core will be completely responsible for Sub-Objective 3. In order to accomplish this sub-objective, the Feasibility Study Core will continue to solicit, review and fund feasibility studies; and to provide ongoing support to funded studies. It is anticipated that at least 50 percent of the feasibility studies will have a genomics focus. The activities of the Feasibility Studies Core will advance knowledge about genetic injury and the influence of gene function on responses to injury.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Exploratory Grants (P20)
Project #
5P20NR007794-05
Application #
7115315
Study Section
Special Emphasis Panel (ZNR1)
Project Start
Project End
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
5
Fiscal Year
2005
Total Cost
$76,436
Indirect Cost
Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Funk, Janet L; Frye, Jennifer B; Davis-Gorman, Grace et al. (2013) Curcuminoids limit neutrophil-mediated reperfusion injury in experimental stroke by targeting the endothelium. Microcirculation 20:544-54
Insel, Kathleen C; Merkle, Carrie J; Hsiao, Chao-Pin et al. (2012) Biomarkers for cognitive aging part I: telomere length, blood pressure and cognition among individuals with hypertension. Biol Res Nurs 14:124-32
Loescher, Lois J; Lim, Kyung Hee; Leitner, Ofri et al. (2009) Cancer surveillance behaviors in women presenting for clinical BRCA genetic susceptibility testing. Oncol Nurs Forum 36:E57-67
Carey, M E; Haut, M W; Reminger, S L et al. (2008) Reduced frontal white matter volume in long-term childhood leukemia survivors: a voxel-based morphometry study. AJNR Am J Neuroradiol 29:792-7
Wung, Shu-Fen; Aouizerat, Bradley E (2008) Candidate genes of the 5-lipoxygenase pathway in acute coronary syndrome: a pilot study. Biol Res Nurs 9:280-92
Wung, Shu-Fen; Kozik, Teri (2008) Electrocardiographic evaluation of cardiovascular status. J Cardiovasc Nurs 23:169-74
Baldwin, Ann L; Bell, Iris R (2007) Effect of noise on microvascular integrity in laboratory rats. J Am Assoc Lab Anim Sci 46:58-65
McEwen, Marylyn Morris; Baird, Martha; Pasvogel, Alice et al. (2007) Health-illness transition experiences among Mexican immigrant women with diabetes. Fam Community Health 30:201-12
Merkle, Carrie J; Torres, Bonny J; Baruch, Jean M et al. (2005) In vitro age-related responses of endothelial cells to breast cancer cell addition. Cancer Detect Prev 29:518-27