This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot study develops instruments needed to assess environmental factors (diet, physical activity and stress) and genetic factors (family history of cardiovascular disease and a few genes that regulate vessel flexibility) that may impact on vascular function. Their reproducibility and validity are assessed in the context of three-generation African-American families. The hypertensive set includes the proband, i.e., the person with hypertension who serves as index person to recruit his/her family, the proband s spouse, offspring aged eight or more, first degree relatives, and parents. A control person, i.e, normotensive, is matched by age and gender to the hypertensive proband and his/her 3-generation family recruited to form the normotensive. The participants are seen once except for the members of the core family (proband, spouse and offspring) who come a second time to the clinic for repeat vascular exam
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