The main purpose of this IDeA Network of Biomedical Research Excellence (INBRE) proposal is to continue to enhance institutional capacity for biomedical and behavioral research in the state of Rhode Island. The University of Rhode Island (URI) is the lead institution, with six partner institutions forming the network. The administrative, bioinformatics, and centralized equipment facility cores at URI will coordinate the four central goals of the next phase: 1) Continue and improve faculty development and mentoring;2) Recruit and train undergraduate and graduate fellows;3) Provide access to state-of-the-art equipment and bioinformatics resources;and 4) Develop new initiatives and collaborations with other infrastructure development programs in the state. Achievement of these goals will be accomplished by collaborative efforts of 19 participating faculty investigators in the network who will carry out research and educational objectives in the focus areas of molecular toxicology, cell biology, and behavioral science. Newly created faculty development programs include research-based collaborative projects and education-based student training initiatives. Proposed projects will focus on a variety of heath-related issues including cancer, neurological diseases, drug metabolism, infectious diseases, tissue regeneration, and the effects of environmental toxins on human health. A new emphasis in bioinformatics, strengthened by increased material and personnel support, will substantially improve the data mining and processing capabilities of biomedical scientists in the state. A productive summer undergraduate research fellowship program, in which students are given rich experiential training in biomedical research methods and career counseling, will be continued. A new collaborative highschool outreach program is planned to provide hands-on research experience for area high school science teachers. It is anticipated that meeting these and other proposed objectives in the next phase of the Rl-INBRE program will continue to have a profound and measurable positive impact on the culture for biomedical and behavioral research and education in the State of Rhode Island.
(provided by the applicant): The proposed research will address a broad range of human health issues. Examples of these include: studies on causes and diagnosis of cancer, neurological diseases, metabolism of drugs and liver disease, parasitic human diseases, regeneration of damaged tissue, and impact of environmental toxins on human health.
|Ma, Hang; Liu, Weixi; Frost, Leslie et al. (2016) Glucitol-core containing gallotannins inhibit the formation of advanced glycation end-products mediated by their antioxidant potential. Food Funct 7:2213-22|
|Masoud, Anwar M; Bihaqi, Syed W; Machan, Jason T et al. (2016) Early-Life Exposure to Lead (Pb) Alters the Expression of microRNA that Target Proteins Associated with Alzheimer's Disease. J Alzheimers Dis 51:1257-64|
|Hui, Wenli; Zhang, Sinong; Zhang, Chao et al. (2016) A novel lateral flow assay based on GoldMag nanoparticles and its clinical applications for genotyping of MTHFR C677T polymorphisms. Nanoscale 8:3579-87|
|Taylor, David L; McNamee, Jason; Lake, John et al. (2016) Juvenile winter flounder (Pseudopleuronectes americanus) and summer flounder (Paralichthys dentatus) utilization of Southern New England nurseries: Comparisons among estuarine, tidal river, and coastal lagoon shallow-water habitats. Estuaries and coasts : journal of the Estuarine Research Federa 39:1505-1525|
|Taylor, David L; Williamson, Patrick R (2016) Mercury contamination in Southern New England coastal fisheries and dietary habits of recreational anglers and their families: Implications to human health and issuance of consumption advisories. Mar Pollut Bull :|
|Donepudi, Ajay C; Cheng, Qiuqiong; Lu, Zhenqiang James et al. (2016) Hepatic Transporter Expression in Metabolic Syndrome: Phenotype, Serum Metabolic Hormones, and Transcription Factor Expression. Drug Metab Dispos 44:518-26|
|Tiwari, Rakesh K; Brown, Alex; Sadeghiani, Neda et al. (2016) Design, Synthesis, and Evaluation of Dasatinib-Amino Acid and Dasatinib-Fatty Acid Conjugates as Protein Tyrosine Kinase Inhibitors. ChemMedChem :|
|Lian, Ting; Hui, Wenli; Li, Xianying et al. (2016) Apolipoprotein E genotyping using PCR-GoldMag lateral flow assay and its clinical applications. Mol Med Rep 14:4153-4161|
|Xu, Jialin; Shimpi, Prajakta; Armstrong, Laura et al. (2016) PFOS induces adipogenesis and glucose uptake in association with activation of Nrf2 signaling pathway. Toxicol Appl Pharmacol 290:21-30|
|Subaiea, Gehad M; Ahmed, Aseef H; Adwan, Lina I et al. (2015) Reduction of amyloid-Î² deposition and attenuation of memory deficits by tolfenamic acid. J Alzheimers Dis 43:425-33|
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