This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Hollow gold nanospheres (HAuNS) possess a unique combination of small size (~40 nm), spherical shape, hollow interior, and strong surface plasmon resonance at near-infrared (NIR) region wavelengths (~800 nm), wherein optical absorption in tissue is minimal and penetration is optimal. We propose to develop a multi-modulated nanotechnology which could be applied to concurrent photothermal therapy and chemotherapy of melanoma. This technology is based on the formulation of cisplatin-loaded HAuNS, where a small peptide, Ac-Glu-Glu-Cys-NH2 (EEC), is designed to serve as both cisplatin coordinator and linker to gold nanoparticles. [Nle4,D-Phe7] alpha?melanocyte-stimulating hormone (NDP-MSH) peptide will be conjugated on the particles as melanoma homing moiety. Through intravenous administration, dual modulation of the drug-loaded nanoparticle will be investigated. First, the particles are expected to have tumor targeting effect and sustained release properties promoting superior anticancer effect and decreased toxicity. Second, upon NIR laser modulation, the combination of photothermal therapy with HAuNS and chemotherapy with laser-controlled drug release may produce a synergistic anticancer effect to overcome tumor regrowth and cisplatin resistance. The success of this technique will be viewed as a paradigm in the treatment of accessible recurrent neoplasms and lead to more effective and patient-compliant treatment over exisitng treatment protocols. This technology may be further explored for application to other cancers and has the potential to produce a major impact in cancer-relevant research.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Rhode Island
Schools of Pharmacy
United States
Zip Code
Ma, Hang; Liu, Weixi; Frost, Leslie et al. (2016) Glucitol-core containing gallotannins inhibit the formation of advanced glycation end-products mediated by their antioxidant potential. Food Funct 7:2213-22
Masoud, Anwar M; Bihaqi, Syed W; Machan, Jason T et al. (2016) Early-Life Exposure to Lead (Pb) Alters the Expression of microRNA that Target Proteins Associated with Alzheimer's Disease. J Alzheimers Dis 51:1257-64
Hui, Wenli; Zhang, Sinong; Zhang, Chao et al. (2016) A novel lateral flow assay based on GoldMag nanoparticles and its clinical applications for genotyping of MTHFR C677T polymorphisms. Nanoscale 8:3579-87
Taylor, David L; McNamee, Jason; Lake, John et al. (2016) Juvenile winter flounder (Pseudopleuronectes americanus) and summer flounder (Paralichthys dentatus) utilization of Southern New England nurseries: Comparisons among estuarine, tidal river, and coastal lagoon shallow-water habitats. Estuaries and coasts : journal of the Estuarine Research Federa 39:1505-1525
Taylor, David L; Williamson, Patrick R (2016) Mercury contamination in Southern New England coastal fisheries and dietary habits of recreational anglers and their families: Implications to human health and issuance of consumption advisories. Mar Pollut Bull :
Donepudi, Ajay C; Cheng, Qiuqiong; Lu, Zhenqiang James et al. (2016) Hepatic Transporter Expression in Metabolic Syndrome: Phenotype, Serum Metabolic Hormones, and Transcription Factor Expression. Drug Metab Dispos 44:518-26
Tiwari, Rakesh K; Brown, Alex; Sadeghiani, Neda et al. (2016) Design, Synthesis, and Evaluation of Dasatinib-Amino Acid and Dasatinib-Fatty Acid Conjugates as Protein Tyrosine Kinase Inhibitors. ChemMedChem :
Lian, Ting; Hui, Wenli; Li, Xianying et al. (2016) Apolipoprotein E genotyping using PCR-GoldMag lateral flow assay and its clinical applications. Mol Med Rep 14:4153-4161
Xu, Jialin; Shimpi, Prajakta; Armstrong, Laura et al. (2016) PFOS induces adipogenesis and glucose uptake in association with activation of Nrf2 signaling pathway. Toxicol Appl Pharmacol 290:21-30
Subaiea, Gehad M; Ahmed, Aseef H; Adwan, Lina I et al. (2015) Reduction of amyloid-β deposition and attenuation of memory deficits by tolfenamic acid. J Alzheimers Dis 43:425-33

Showing the most recent 10 out of 359 publications