This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective and public-health relevance: Ongoing research in our laboratory is devoted to developing animal models to measure the behavioral phenomenology related to substance-dependence disorders. In particular, we hope to identify the neurotransmitter pathways involved in the development of and relapse to stimulant dependence.
Specific aims : The experiments proposed involve the differential-reinforcement-of-low-rate responding (DRL) schedule. The DRL schedule has been described as a model of impulsive behavior, and DRL performance is dose-dependently impaired by single doses of nicotine. Furthermore, repeated administration of nicotine results in profound perturbations on DRL-schedule behavior. This finding suggests that impulsivity is among the category of behaviors that exhibit sensitization to repeated nicotine exposure. Research design: The proposed experiments will evaluate whether sensitization of DRL-schedule performance is the result of dopaminergic or acetylcholinergic-receptor modifications. Nicotine and dl-amphetamine will be used to produce sensitization-induced impulsivity. The objective is to discover whether mecamylamine (a nicotinic-antagonist) can attenuate the effects of both stimulants, and if so, then sensitization of impulsivity may result from acetylcholine-receptor modification. Relatedness of the project: The animal behavior laboratory at Saint Michael's College is in its infancy but has already become an excellent resource for the students in psychology to engage in an active research program.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016462-10
Application #
8360432
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Project Start
2011-06-01
Project End
2012-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
10
Fiscal Year
2011
Total Cost
$67,073
Indirect Cost
Name
University of Vermont & St Agric College
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Spritzer, M D; Curtis, M G; DeLoach, J P et al. (2016) Sexual interactions with unfamiliar females reduce hippocampal neurogenesis among adult male rats. Neuroscience 318:143-56
Hinkle, Karen L; Anderson, Chad C; Forkey, Blake et al. (2016) Exposure to the lampricide 3-trifluoromethyl-4-nitrophenol results in increased expression of carbohydrate transporters in Saccharomyces cerevisiae. Environ Toxicol Chem 35:1727-32
Nock, Adam M; Wargo, Matthew J (2016) Choline Catabolism in Burkholderia thailandensis Is Regulated by Multiple Glutamine Amidotransferase 1-Containing AraC Family Transcriptional Regulators. J Bacteriol 198:2503-14
Symeonides, Menelaos; Murooka, Thomas T; Bellfy, Lauren N et al. (2015) HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts. Viruses 7:6590-603
Xie, Yi; Jin, Yu; Merenick, Bethany L et al. (2015) Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition. Sci Signal 8:ra44
Case, Laure K; Wall, Emma H; Osmanski, Erin E et al. (2015) Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring. Genome Biol 16:28
Perkins, Timothy N; Peeters, Paul M; Shukla, Arti et al. (2015) Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells. Hum Mol Genet 24:1374-89
Kirshenbaum, Ari; Green, John; Fay, Michael et al. (2015) Reinforcer devaluation as a consequence of acute nicotine exposure and withdrawal. Psychopharmacology (Berl) 232:1583-94
Bentley, P A; Wall, E H; Dahl, G E et al. (2015) Responses of the mammary transcriptome of dairy cows to altered photoperiod during late gestation. Physiol Genomics 47:488-99
Mireault, Gina C; Crockenberg, Susan C; Sparrow, John E et al. (2015) Laughing matters: Infant humor in the context of parental affect. J Exp Child Psychol 136:30-41

Showing the most recent 10 out of 173 publications