This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall goal of the proposed pilot project research is to investigate plasticity in carbohydrate metabolism and transport (CMT) gene expression under conditions of temperature stress in the newly emerging ecological model species, Arabidopsis lyrata.
The specific aims of the proposed research are 1) to use bioinformatics methods to analyze high throughput genomic sequence data for significant population level allele polymorphism and evidence of adaptive evolution in CMT genes in individuals from three populations and 2) to perform follow-up gene expression studies using quantitative RT-PCR on specific genes identified in the bioinformatics analysis. The results of these studies are expected to provide some support for the hypothesis that phenotypic plasticity is conferred by divergence in gene or allele expression in response to different environmental conditions. These data may then provide support for a full proposal to more thoroughly investigate gene duplicate and allele divergence mechanisms for the evolution of physiological plasticity in carbohydrate metabolism and transport.
|Spritzer, M D; Curtis, M G; DeLoach, J P et al. (2016) Sexual interactions with unfamiliar females reduce hippocampal neurogenesis among adult male rats. Neuroscience 318:143-56|
|Hinkle, Karen L; Anderson, Chad C; Forkey, Blake et al. (2016) Exposure to the lampricide 3-trifluoromethyl-4-nitrophenol results in increased expression of carbohydrate transporters in Saccharomyces cerevisiae. Environ Toxicol Chem 35:1727-32|
|Nock, Adam M; Wargo, Matthew J (2016) Choline Catabolism in Burkholderia thailandensis Is Regulated by Multiple Glutamine Amidotransferase 1-Containing AraC Family Transcriptional Regulators. J Bacteriol 198:2503-14|
|Symeonides, Menelaos; Murooka, Thomas T; Bellfy, Lauren N et al. (2015) HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts. Viruses 7:6590-603|
|Xie, Yi; Jin, Yu; Merenick, Bethany L et al. (2015) Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition. Sci Signal 8:ra44|
|Case, Laure K; Wall, Emma H; Osmanski, Erin E et al. (2015) Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring. Genome Biol 16:28|
|Perkins, Timothy N; Peeters, Paul M; Shukla, Arti et al. (2015) Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells. Hum Mol Genet 24:1374-89|
|Kirshenbaum, Ari; Green, John; Fay, Michael et al. (2015) Reinforcer devaluation as a consequence of acute nicotine exposure and withdrawal. Psychopharmacology (Berl) 232:1583-94|
|Bentley, P A; Wall, E H; Dahl, G E et al. (2015) Responses of the mammary transcriptome of dairy cows to altered photoperiod during late gestation. Physiol Genomics 47:488-99|
|Mireault, Gina C; Crockenberg, Susan C; Sparrow, John E et al. (2015) Laughing matters: Infant humor in the context of parental affect. J Exp Child Psychol 136:30-41|
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